ArticleInternational orthopaedics2015
Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.
Article in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Cell-Free Scaffolds in Cartilage Knee Surgery: A Systematic Review and Meta-Analysis of Clinical Evidence.Cartilage · 2021Pooled it
- Multi-Omics Profiling Reveals Immunomodulatory and Pro-Regenerative Effects of a Graphene Oxide-Collagen Scaffold in Massive Rotator Cuff Tears.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Coefficient of Friction and Height Loss: Two Criteria Used to Determine the Mechanical Property and Stability of Regenerated Versus Natural Articular Cartilage.Biomedicines · 2022Article
- Decellularized Avian Cartilage, a Promising Alternative for Human Cartilage Tissue Regeneration.Materials (Basel, Switzerland) · 2022Article
- Current Advances in the Regeneration of Degenerated Articular Cartilage: A Literature Review on Tissue Engineering and Its Recent Clinical Translation.Materials (Basel, Switzerland) · 2021Review
- The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Compression Bioreactor-Based Mechanical Loading Induces Mobilization of Human Bone Marrow-Derived Mesenchymal Stromal Cells into Collagen Scaffolds In Vitro.International journal of molecular sciences · 2020Article
- Evaluation of a Cell-Free Collagen Type I-Based Scaffold for Articular Cartilage Regeneration in an Orthotopic Rat Model.Materials (Basel, Switzerland) · 2020Article
- BMSCs-assisted injectable Col I hydrogel-regenerated cartilage defect by reconstructing superficial and calcified cartilage.Regenerative biomaterials · 2020Article
- Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects.Materials (Basel, Switzerland) · 2020Review
- What parameters affect knee function in patients with untreated cartilage defects: baseline data from the German Cartilage Registry.International orthopaedics · 2019Article
- Article
- Comment on Roessler et al.: Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.International orthopaedics · 2016Article
- Comment on Roessler et al.: Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.International orthopaedics · 2016Article
- Post-decellularization techniques ameliorate cartilage decellularization process for tissue engineering applications.Journal of tissue engineeringReview
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough there are various new scaffold-based techniques for cartilage regeneration it remains unclear up to which defect size they can be used. The present study reports of a cell-free collagen type I gel matrix for the treatment of large cartilage defects of the knee after a two-year follow-up.
methodsTwenty-eight patients with a mean cartilage defect size of 3.71 ± 1.93 cm² were treated with a cell-free collagen type I gel matrix (CaReS-1S®, Arthro Kinetics AG, Krems/Donau, Austria) via a mini-arthrotomy. Clinical outcome was assessed preoperatively and six weeks as well as six, 12 and 24 months after surgery using various clinical outcome scores (IKDC, Tegner, KOOS, VAS). Cartilage regeneration was evaluated via MRI using the MOCART score.
resultsSeventeen male and 11 female patients with a mean age of 34.6 years were included in this study. Significant pain reduction (VAS) could be noted after six weeks already. Patient activity (IKDC, Tegner) could be significantly improved from 12 months on and nearly reached reported pre-operative values. All subject categories of the KOOS except for symptom (swelling) showed significant improvements throughout the study. Constant significant improvements of the mean MOCART score were observed from 12 months on. MR images did not yield any signs of infection or synovitis. After 24 months a complete defect filling could be noted in 24 out of 28 cases with a mainly smooth surface, complete integration of the border zone and homogenous structure of the repaired tissue.
conclusionCell-free collagen type I matrices appear to be a safe and suitable treatment option even for large cartilage defects of the knee. Results of this study were comparable to the better-established findings for small cartilage defects. Mid- and long-term results will be needed to see if clinical and MR-tomographic outcome can be maintained beyond 24 months.
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