ArticleActa biomaterialia2015
Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 111 citations in OpenAlex.
- Next-Generation Hydrogel Skin Adhesives: From Bioinspired Adhesion Chemistry to Regenerative Wound Interfaces.Advanced healthcare materials · 2026Review
- Reprogrammed SimCells for antimicrobial therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Exploring olive mill wastewater as a reservoir of antimicrobial and antioxidant compounds: insights from a cross-regional Moroccan study.Frontiers in microbiology · 2026Article
- Autoxidation-Induced Curing of 6-Hydroxycatechol-Containing Adhesive.Macromolecular chemistry and physics · 2025Article
- Accelerated dermal wound healing in diabetic mice by a HJournal of materials chemistry. B · 2025Article
- Biocompatibility of mussel-inspired water-soluble tissue adhesives.Journal of biomedical materials research. Part A · 2024Article
- Utilizing Rapid Hydrogen Peroxide Generation from 6-Hydroxycatechol to Design Moisture-Activated, Self-Disinfecting Coating.ACS applied materials & interfaces · 2024Article
- Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.Advanced healthcare materials · 2024Article
- Acrylate monomer polymerization triggered by iron oxide magnetic nanoparticles and catechol containing microgels.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair.Polymers · 2023Article
- Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS.Bioactive materials · 2023Article
- Engineering a naturally derived hemostatic sealant for sealing internal organs.Materials today. Bio · 2022Article
- Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration.Bioactive materials · 2021Article
- Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives.Nature communications · 2021Article
- Oxidation Chemistry of Catechol Utilized in Designing Stimuli-Responsive Adhesives and Antipathogenic Biomaterials.ACS omega · 2021Review
- Catechol-Based Antimicrobial Polymers.Molecules (Basel, Switzerland) · 2021Review
- Inspired by nature: facile design of nanoclay-organic hydrogel bone sealant with multifunctional properties for robust bone regeneration.Advanced functional materials · 2020Article
- Hydroxyl Radical Generation Through the Fenton-Like Reaction of Hematin- and Catechol-Functionalized Microgels.Chemistry of materials : a publication of the American Chemical Society · 2020Article
- Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering.Biomaterials science · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of H2O2 when its catechol side chain oxidized to quinone. Introduction of catalase at a concentration as low as 7.5 U/mL counteracted the cytotoxic effect of H2O2 and enhanced the viability and proliferation rate of fibroblasts. These results indicated that H2O2 generation is one of the main contributors to the cytotoxicity of dopamine in culture. Additionally, catalase is a potentially useful supplement to suppress the elevated oxidative stress found in typical culture conditions and can more accurately evaluate the biocompatibility of mussel-mimetic biomaterials. The release of H2O2 also induced a higher foreign body reaction to catechol-modified hydrogel when it was implanted subcutaneously in rat. Given that H2O2 has a multitude of biological effects, both beneficiary and deleterious, regulation of H2O2 production from catechol-containing biomaterials is necessary to optimize the performance of these materials for a desired application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.