Evidence map›Paper›PMID 25676570›Full record

ArticleMolecular and cellular endocrinology2015

FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.

Danalea V Skarra, Varykina G Thackray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Mechanistic insights into the role of FOXO in diabetic retinopathy.American journal of translational research · 2022
    Review
  2. Article
  3. Article
  4. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.Clinical, cosmetic and investigational dermatology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Danalea V SkarraDepartment of Reproductive Medicine and the Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Varykina G ThackrayDepartment of Reproductive Medicine and the Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: vthackray@ucsd.edu.
University of California, San Diego · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
The Interaction of Neuroendocrine Repro. Function and Metabolic SignalingU54HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 1999 to 2013
$18.0M
The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2020
$7.5M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
Transcriptional control of pituitary gonadotropin genesR01HD067448 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THACKRAY, VARYKINA G · 2011 to 2015
$1.6M
Endocrine Network for Undergraduate Research and Carrier Development OpportunitieT36GM095349 · NIGMS · ENDOCRINE SOCIETY · PI ANDERSON, STEVEN M, LAAKSO, JOSEPH M · 2011 to 2015
$1.1M
FoxO1 signaling in pituitary gonadotropesF32HD074414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SKARRA, DANALEA · 2013 to 2014
$102k
NICHD NIH HHS F32 HD074414NICHD NIH HHS P50 HD012303NICHD NIH HHS R01 HD067448NICHD NIH HHS T32 HD007203NICHD NIH HHS U54 HD012303NIGMS NIH HHS K12 GM068524NIGMS NIH HHS T36 GM095349
6 · The paper itself

Abstract

The FOXO1 transcription factor is important for multiple aspects of reproductive function. We previously reported that FOXO1 functions as a repressor of gonadotropin hormone synthesis, but how FOXO1 is regulated in pituitary gonadotropes is unknown. The growth factors, insulin and insulin-like growth factor I (IGF1), function as key regulators of cell proliferation, metabolism and apoptosis in multiple cell types through the PI3K/AKT signaling pathway. In this study, we found that insulin and IGF1 signaling in gonadotropes induced FOXO1 phosphorylation through the PI3K/AKT pathway in immortalized and primary cells, resulting in FOXO1 relocation from the nucleus to the cytoplasm. Furthermore, insulin administration in vivo induced phosphorylation of FOXO1 and AKT in the pituitary. Thus, insulin and IGF1 act as negative regulators of FOXO1 activity and may serve to fine-tune gonadotropin expression.

Indexed as

AnimalsCell LineForkhead Box Protein O1Forkhead Transcription FactorsGonadotrophsGonadotropin-Releasing HormoneInsulinInsulin-Like Growth Factor IMicePhosphorylationProtein Processing, Post-TranslationalProtein TransportProto-Oncogene Proteins c-aktForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mouseGonadotropin-Releasing HormoneInsulininsulin-like growth factor-1, mouseInsulin-Like Growth Factor IProto-Oncogene Proteins c-aktForkhead box O1GnRHGonadotropeIGF1Insulin

Identifiers

PMID25676570
PMCPMC4363278
OpenAlexW2077649854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.