Evidence map›Paper›PMID 25676522›Full record

ReviewClinics in chest medicine2015

Nontuberculous mycobacteria infections in immunosuppressed hosts.

Emily Henkle, Kevin L Winthrop

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Clinics in chest medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463134 (A Prospective Observational Study of Parameters Related to the Clinical Outcomes of NTM Pulmonary Disease in Prince of Wales Hospital), which is not on this map. Cited by 177 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04463134 unknown statusnot on this mapstarted 2020, after this paper: background citation

A Prospective Observational Study of Parameters Related to the Clinical Outcomes of NTM Pulmonary Disease in Prince of Wales Hospital

TypeobservationalSponsorChinese University of Hong KongRan2020 to 2023Enrolled50ConditionsClinical OutcomesArmsNTM drug treatment
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 2 syntheses or guidelines pooled it, 316 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Trial
  4. Article
  5. Article
  6. Article
  7. Antibiotics (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Cutaneous non-tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Description and complete genome sequence ofFrontiers in microbiology · 2026
    Article
  18. Clinical, cosmetic and investigational dermatology · 2026
    Article
  19. Article
  20. Article

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Emily HenkleHIV, STD, and TB Section, Public Health Division, Oregon Health Authority, 800 NE Oregon Street, Suite 1105, Portland, OR 97232, USA. Electronic address: emhenkle@gmail.com.
Kevin L WinthropDivision of Infectious Diseases, Oregon Health and Science University, 3375 Southwest Terwilliger Boulevard, Mailstop CEI, Portland, OR 97239, USA; Division of Public Health and Preventative Medicine, Oregon Health and Science University, 3375 Southwest Terwilliger Boulevard, Mailstop CEI, Portland, OR 97239, USA.
Oregon Health Authority · USOregon Health & Science University · US

Funding

NIAID NIH HHS HHSN272201200005C
6 · The paper itself

Abstract

Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Extrapulmonary NTM disease, including disseminated, skin, and catheter-related disease, is more common in immunosuppressed than immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection, but rapid growers including Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum play an important role in skin and catheter-related infections. With the exception of antibiotic prophylaxis for AIDS patients, the prevention of NTM remains difficult. Management is complicated, involving restoration of immune function and removal of catheters in addition to treatment with species-specific antibiotics per current guidelines.

Indexed as

Immunocompromised HostAnti-Bacterial AgentsDrug Administration ScheduleHumansImmunosuppressive AgentsLung DiseasesMycobacterium Infections, NontuberculousNontuberculous MycobacteriaAnti-Bacterial AgentsImmunosuppressive AgentsExtrapulmonary nontuberculous mycobacteriaImmunosuppressive therapyMycobacterium aviumTransplant

Identifiers

PMID25676522
PMCPMC4710582
OpenAlexW1973872876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.