ReviewInflammation2015
The Specific Roles of JAK/STAT Signaling Pathway in Sepsis.
Review in Inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 131 citations in OpenAlex.
- Anti-Inflammatory Interleukins in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Article
- Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review).International journal of molecular medicine · 2026Review
- Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Esmolol Alleviates Sepsis-Associated Myocardial Injury by Acting on the APAF1 and JAK2/STAT3 Inflammatory Pathways.Cardiovascular therapeutics · 2026Article
- The role of Epstein-Barr virus in NK/T cell lymphoproliferative disorders: molecular mechanisms and potential therapeutic strategies.Frontiers in immunology · 2026Review
- Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS-STING, and NF-κB networks in sepsis.Frontiers in cell and developmental biology · 2026Review
- Excessive activation of JAK-STAT signaling contributes to inflammation induced by acuteVirulence · 2025Article
- Sepsis toxicity network reconstruction-Dynamic signaling and multi-organ injury: A review.Biomolecules & biomedicine · 2025Review
- IL-1R2 as a Precision Therapeutic Target in Sepsis: Molecular Insights into Immune Regulation.Current issues in molecular biology · 2025Article
- Convergence of sepsis-associated encephalopathy pathogenesis onto microglia.Journal of translational medicine · 2025Review
- Identification of Subtypes and Diagnostic Markers Related to Necroptosis in Sepsis.Applied biochemistry and biotechnology · 2025Article
- FGF-Mediated Axon Guidance: Role of Downstream Signaling Pathways in Cytoskeletal Control.Cells · 2025Review
- microRNA-34 mediates a negative feedback loop in the JAK-STAT pathway to attenuate immune overactivation in an invertebrate.Cell communication and signaling : CCS · 2025Article
- ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer.Molecular cancer · 2025Article
- The Dual-Edged Sword: Risks and Benefits of JAK Inhibitors in Infections.Pathogens (Basel, Switzerland) · 2025Review
- Traditional Chinese medicine in the treatment ofWorld journal of gastroenterology · 2025Review
- Redefining cell death: ferroptosis as a game-changer in ophthalmology.Frontiers in immunology · 2025Review
- Pyroptosis-Related Genes as Prognostic Biomarkers and Immune Infiltration Features in Sepsis-Induced ARDS: A Single-Cell and Bulk RNA-Sequencing Analysis.Journal of inflammation research · 2025Article
- Decoding Sepsis: Unraveling Key Signaling Pathways for Targeted Therapies.Research (Washington, D.C.) · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is a principal signaling pathway for the signal transduction of many pivotal cytokines involved in sepsis. Binding of cytokines to corresponding receptors can activate associated JAK kinases, which selectively phosphorylate STATs. Activated STATs then translocate to the nucleus and play a critical role in the transcription of target genes. During the past several years, significant progress has been made in the understanding of the roles of JAK/STAT pathway in sepsis. The aims of this review are to describe the present knowledge about JAK/STAT signaling pathway, describe the specific roles of JAK/STAT pathway in sepsis, and put forward the prospect for future studies of JAK/STAT signaling pathway in sepsis. A PubMed database search was performed for studies of JAKs and STATs in sepsis. It has been shown that a variety of cytokines can exert their biological effects via the JAK/STAT signaling pathway. JAK/STAT pathway has been shown related to the release of various cytokines and inflammatory mediators and involved in the regulation of immune response in sepsis. Moreover, JAK/STAT pathway has been shown involved in organ damage and other dysfunctions in sepsis models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.