ArticleJournal of magnetic resonance imaging : JMRI2015
Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 69 citations in OpenAlex.
- Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states - A direct comparison withJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Trial
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- Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Blood-Brain Barrier Permeability Is Elevated in Type 2 Diabetes and Obesity: Associations with Cognitive Function and Metabolic Markers.Research square · 2026Article
- Non-Contrast Assessment of Blood-Brain Barrier Permeability to Water: Improved Signal Modeling and Data Acquisition.Magnetic resonance in medicine · 2026Article
- Using flow ratio of peritumoral artery/renal aorta from DSA imaging to predict high-risk clear cell renal cell carcinoma.World journal of urology · 2026Article
- Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.Brain communications · 2026Article
- Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis.Frontiers in cardiovascular medicine · 2026Article
- Arterial-optimized 4D-flow MRI for quantifying flow and pulsatility in venous sinuses and large cerebral veins.Scientific reports · 2025Article
- Blood-Brain barrier disruption in long COVID and cognitive correlates: A cross-sectional MRI study.Brain, behavior, and immunity · 2025Article
- Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study.Health and metabolism · 2025Article
- Tortuous extracranial arteries contribute to white Matter hyperintensities in aging brains.Frontiers in aging neuroscience · 2025Article
- Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults.Frontiers in neuroscience · 2025Article
- Altered cerebral oxygen extraction and metabolism in preterm neonates and the relationship to anemia: A noncontrast MRI study.Annals of the Child Neurology Society · 2024Article
- VICTR: Venous transit time imaging by changes in TMagnetic resonance in medicine · 2024Article
- Automated Quantification of Total Cerebral Blood Flow from Phase-Contrast MRI and Deep Learning.Journal of imaging informatics in medicine · 2024Article
- Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system.Frontiers in psychiatry · 2024Review
- Metabolic and vascular imaging markers for investigating Alzheimer's disease complicated by sleep fragmentation in mice.Frontiers in physiology · 2024Article
- Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWhole-brain cerebral blood flow (CBF) measured by phase-contrast MRI (PC-MRI) provides an important index for brain function. This work aimed to optimize the PC-MRI imaging protocol for accurate CBF measurements.
methodsTwo studies were performed on a 3 Tesla system. In Study 1 (N = 12), we optimized in-plane resolution of PC-MRI acquisition for CBF quantification by considering accuracy, precision, and scan duration. In Study 2 (N = 7), we assessed the detrimental effect of nonperpendicular imaging slice orientation on CBF quantification. Both One-way analysis of variance with repeated measurement and Friedman test were used to examine the effects of resolution and angulation on CBF quantification. Additionally, we evaluated the inter-rater reliability in PC-MRI data processing.
resultsOur results showed that CBF measurement with 0.7 mm resolution could be overestimated by up to 13.3% when compared with 0.4 mm resolution. Moreover, CBF could also be overestimated by up to 18.8% when the slice orientation is deviated by 30° from the ideal angulation. However, within 10° of the ideal slice orientation, estimated CBF was not significantly different from each other (P = 0.23 and 0.45 for internal carotid artery and vertebral artery, respectively). Inter-rater difference was <3%.
conclusionFor fast and accurate quantification of whole-brain CBF with PC-MRI, we recommend the use of an imaging resolution of 0.5 mm and a slice orientation that is less than 10° from vessel's axial plane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.