Trial reportSurgical endoscopy2015
Evaluation of safety profile of thoracoscopic esophagectomy for T1bN0M0 cancer using data from JCOG0502: a prospective multicenter study.
Trial report in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- A Systematic Mapping Review of Core Outcome Reporting in Surgical Research for Oesophageal Cancer.Journal of surgical oncology · 2026Pooled it
- Pooled it
- A randomized controlled trial exploring the effect of placement versus nonplacement of a drainage tube around the cervical anastomosis in McKeown esophagectomy.Scientific reports · 2025Trial
- Esophageal nerve sheath tumor: A rare benign tumor with diagnostic challenges-A case report.SAGE open medical case reports · 2026Article
- Development in Esophagectomy for Esophageal Cancer: The Current Standing Point of Robotic Surgery.Cancers · 2025Review
- Additional chemoradiotherapy following endoscopic submucosal dissection in patients with esophageal squamous cell carcinoma: a narrative review.Frontiers in oncology · 2025Review
- Treatment strategy for early-stage esophageal cancer.Japanese journal of radiology · 2024Review
- No difference in the incidence of postoperative pulmonary complications between abdominal laparoscopy and laparotomy for minimally invasive thoracoscopic esophagectomy: a retrospective cohort study using a nationwide Japanese database.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Factors influencing decision-making between surgery and chemoradiotherapy for esophageal carcinoma from the JCOG0502.Future oncology (London, England) · 2024Article
- The Utility of Indocyanine Green Angiography in the Assessment of Perfusion of Gastric Conduit and Proximal Esophageal Stump Against Visual Assessment in Patients Undergoing Esophagectomy: a Prospective Study.Indian journal of surgical oncology · 2020Article
- Prevention of intra-thoracic recurrent laryngeal nerve injury with robot-assisted esophagectomy.Langenbeck's archives of surgery · 2020Article
- Postoperative complications of minimally invasive esophagectomy for esophageal cancer.Annals of gastroenterological surgery · 2020Review
- Article
- Current status of minimally invasive esophagectomy for esophageal cancer: Is it truly less invasive?Annals of gastroenterological surgery · 2019Review
- Assessment of the blood supply using the indocyanine green fluorescence method and postoperative endoscopic evaluation of anastomosis of the gastric tube during esophagectomy.Surgical endoscopy · 2018Article
- Impact of laparoscopy on the prevention of pulmonary complications after thoracoscopic esophagectomy using data from JCOG0502: a prospective multicenter study.Surgical endoscopy · 2018Article
- Impact of unplanned events on early postoperative results of minimally invasive esophagectomy.Thoracic cancer · 2018Article
- Efficacy of COGeneral thoracic and cardiovascular surgery · 2017Article
- Endotherapy in case of relapse of neoplastic Barrett's esophagus after successful initial endoscopic resection.Surgical endoscopy · 2017Article
- Current Advancement in Multidisciplinary Treatment for Resectable cStage II/III Esophageal Squamous Cell Carcinoma in Japan.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThoracoscopic esophagectomy is rapidly and increasingly being used worldwide because it is a less invasive alternative to open esophagectomy. However, few prospective multicenter studies have evaluated its safety profile. This study aimed to evaluate the safety profile of thoracoscopic esophagectomy using perioperative data from the Japan Clinical Oncology Group Study (JCOG0502).
methodsJCOG0502 is a four-arm prospective study comparing esophagectomy with chemoradiotherapy for esophageal cancer, with randomized and patient preference arms. Patients with clinical stage T1bN0M0 esophageal cancer were enrolled until patient accrual was completed. Open or thoracoscopic esophagectomy was selected at the surgeon's discretion. Perioperative complications were defined as adverse events of ≥grade 2 as per Common Terminology Criteria for Adverse Events ver. 3.0.
resultsA total of 379 patients were enrolled between December 2006 and February 2013. Of the 210 patients who underwent surgery, 109 patients underwent open esophagectomy, and 101 patients underwent thoracoscopic esophagectomy. Although thoracoscopic esophagectomy decreased the incidence of postoperative atelectasis (open: 22.0%, thoracoscopy: 10.9%; P = 0.041), reoperation was more frequent in the thoracoscopy group (open: 1.8%, thoracoscopy: 9.9%; P = 0.016). The incidence of overall complications did not differ between the two groups (open: 44.0%, thoracoscopy: 44.6%; P = 1.00). There was one in-hospital death in each group (open: 0.9%, thoracoscopy: 1.0 %; P = 1.00).
conclusionsThoracoscopic esophagectomy is a safe procedure with morbidity and mortality comparable with those of open esophagectomy. However, it is associated with a higher frequency of reoperation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.