Evidence map›Paper›PMID 25676147›Full record

Trial reportJournal of neurointerventional surgery2016

Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial.

Sunil A Sheth, Reza Jahan, Elad I Levy, Tudor G Jovin, Blaise Baxter, Raul G Nogueira, Wayne Clark, Ronald Budzik, Osama O Zaidat, Jeffrey L Saver and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurointerventional surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Procedural factors associated with successful recanalization in patients with acute ischemic stroke treated with endovascular thrombectomy-a nationwide register-based observational study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sunil A ShethDepartment of Radiology and Stroke Center, University of California, Los Angeles, Los Angeles, California, USA.
Reza JahanDepartment of Radiology and Stroke Center, University of California, Los Angeles, Los Angeles, California, USA.
Elad I LevyDepartment of Neurosurgery, Millard Fillmore Hospital, Buffalo, New York, USA.
Tudor G JovinDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Blaise BaxterDepartment of Radiology, Erlanger Hospital, Chattanooga, Tennessee, USA.
Raul G NogueiraDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
Wayne ClarkDepartment of Neurology, Oregon Health Science University, Portland, Oregon, USA.
Ronald BudzikDepartment of Radiology, Riverside Methodist Hospital, Columbus, Ohio, USA.
Osama O ZaidatDepartment of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jeffrey L SaverDepartment of Neurology and Stroke Center, University of California, Los Angeles, Los Angeles, California, USA.
SWIFT Trialists

Funding

UCLA SPOTRIAS CENTER APPLICATION RENEWAL-PROGRAM PROJECTP50NS044378 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VINTERS, HARRY V. · 2003 to 2012
$17.2M
Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)U10NS086497 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L, SUNG, GENE YONG · 2013 to 2017
$2.0M
NINDS NIH HHS P50 NS044378NINDS NIH HHS U10 NS086497
6 · The paper itself

Abstract

backgroundIn light of recent positive trial data for endovascular therapy in acute ischemic stroke (AIS), stent retriever use by practitioners without prior experience with these devices may become more common.

objectiveTo assess the safety and efficacy of thrombectomy for AIS using Solitaire for patients treated in the roll-in period of the Solitaire With the Intention For Thrombectomy (SWIFT) trial, which represented the first clinical use of the device for these interventionalists.

methodsProspectively collected demographic, clinical, and angiographic data on patients treated in the initial roll-in and subsequent randomized phases of the SWIFT study were collected and analyzed. Key statistical analyses were validated by an independent external statistician.

resultsPatients in the roll-in period achieved equivalently high rates of reperfusion (55%) compared with those treated with the device in the randomized phase (61%). Rates of adverse events were comparable (13% vs. 9%). Rates of good neurological outcome were equivalent between the roll-in and randomized patients treated with Solitaire (63% vs. 58%). Including the roll-in patients strengthened the conclusions of the study, that reperfusion rates without symptomatic hemorrhage with Solitaire were greater than with Merci (59% vs. 24%, p<0.001).

conclusionsThrombectomy in AIS using the Solitaire stent retriever device can be performed safely and effectively when used by experienced neurointerventionalists without previous experience with the device. TRIAL REGISTRATION NUMBER: The SWIFT study is registered with ClinicalTrials.gov, number NCT 01054560.

Indexed as

Learning CurveStentsAgedAged, 80 and overBrain IschemiaFemaleHumansMaleMiddle AgedProspective StudiesStrokeSurvival RateThrombectomyAngiographyInterventionStrokeTechniqueThrombectomy

Identifiers

PMID25676147
PMCPMC4955564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.