ArticleJournal of molecular neuroscience : MN2015
17β-Estradiol Upregulated Expression of α and β Subunits of Larger-Conductance Calcium-Activated K(+) Channels (BK) via Estrogen Receptor β.
Article in Journal of molecular neuroscience : MN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Sex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APPBiology of sex differences · 2025Article
- Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.Journal of muscle research and cell motility · 2025Review
- Global burden of childhood otitis media attributable to secondhand smoke from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in pediatrics · 2025Article
- Estrogenic Modulation of Ionic Channels, Pumps and Exchangers in Airway Smooth Muscle.International journal of molecular sciences · 2023Review
- Sex differences in pituitary corticotroph excitability.Frontiers in physiology · 2023Article
- Article
- Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022Article
- The modulation of potassium channels by estrogens facilitates neuroprotection.Frontiers in cell and developmental biology · 2022Review
- Estrogen-induced downregulation of TASK-1 expression through estrogen receptor β in N2A cells.Molecular biology reports · 2022Article
- Sex differences in lower urinary tract biology and physiology.Biology of sex differences · 2018Review
- Chronic interval exercise training prevents BKJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.International journal of molecular sciences · 2018Article
- Down-Regulation of CaInternational journal of molecular sciences · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-conductance Ca(2+)-activated K(+) channels, which were known as BK channels, were widely distributed in brain tissues and played a crucial role in neuroprotection. Previous studies found that estrogen, a steroid hormone, was able to interact with distinct K(+) channels such as Kv (voltage-gated K(+) channels) in various tissues. However, current knowledge about possible effects of estrogen on BK channels is rather poor. In the present study here, the investigation for the interaction of estrogen with BK channels was performed in mouse N2A cells and human SK-N-SH cells. At first, the different expression patterns of α and β subunits of BK channels in these cells were explored by conducting RT-PCR. After exposure to varying dose of 17β-estradiol (E2) for 24 h, the messenger RNA (mRNA) levels of these BK channel subunits in both N2A and SK-N-SH cells were significantly increased in a concentration-dependent way. A prolonged incubation for 48 h also potentiated the effects of E2 on β1 and β4 subunits in N2A cells as well as α and β3 subunits in SK-N-SH cells. The small interfering RNAs (siRNAs) against the ERα (siERα) or ERβ (siERβ) was induced into N2A and SK-N-SH cells by transfection and resulted in a decrease in the level of corresponding ER transcript. Furthermore, treatment with siERβ but not siERα attenuated the action of E2 on BK channel subunits, suggesting that estradiol exerted its action by binding to ERβ. Our data indicated that 17β-estradiol was able to regulate the expression of BK channel subunits via ERβ.
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