ArticleCell and tissue research2015
Response of stem cells from different origins to biphasic calcium phosphate bioceramics.
Article in Cell and tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Germanium-doped calcium phosphate ceramics in combination with mesenchymal stem cells derived from the neural crest, obtained from rabbit vibrissae: an experimental model of rabbit jaw regeneration.Archives of craniofacial surgery · 2026Article
- The Immunologic Spectrum of Biostimulators and Its Clinical Importance.Plastic and reconstructive surgery. Global open · 2025Article
- Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation.Molecular oncology · 2025Article
- Article
- Recent progress and clinical applications of advanced biomaterials in cosmetic surgery.Regenerative biomaterials · 2023Review
- Influence of Bone Substitutes on Mesenchymal Stromal Cells in an Inflammatory Microenvironment.International journal of molecular sciences · 2022Article
- The effectiveness of hydroxyapatite-beta tricalcium phosphate incorporated into stem cells from human exfoliated deciduous teeth for reconstruction of rat calvarial bone defects.Clinical oral investigations · 2022Article
- Bone regeneration of a polymeric sponge technique-Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull.Clinical and experimental dental research · 2021Article
- Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars.International journal of environmental research and public health · 2021Article
- Restoring Facial Contour and Harmony Using Biphasic Calcium Phosphate Bioceramics.Plastic and reconstructive surgery. Global open · 2021Article
- Influence of Mesenchymal Stem Cell Sources on Their Regenerative Capacities on Different Surfaces.Cells · 2021Article
- 3D Poly(Lactic Acid) Scaffolds Promote Different Behaviors on Endothelial Progenitors and Adipose-Derived Stromal Cells in Comparison With Standard 2D Cultures.Frontiers in bioengineering and biotechnology · 2021Article
- PEOT/PBT Polymeric Pastes to Fabricate Additive Manufactured Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Article
- Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics.Scientific reports · 2020Article
- A specific affinity cyclic peptide enhances the adhesion, expansion and proliferation of rat bone mesenchymal stem cells on β‑tricalcium phosphate scaffolds.Molecular medicine reports · 2019Article
- The Applications of 3D Printing for Craniofacial Tissue Engineering.Micromachines · 2019Review
- The Influences of Different Ratios of Biphasic Calcium Phosphate and Collagen Augmentation on Posterior Lumbar Spinal Fusion in Rat Model.Yonsei medical journal · 2017Article
- The Angiogenic Potential of DPSCs and SCAPs in anStem cells international · 2017Article
- Article
- 3D bioprinting and craniofacial regeneration.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biphasic calcium phosphate (BCP) bioceramics have been successfully applied in a broad variety of presentation forms and with different ratios of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). BCPs have been loaded with stem cells from different origins for bone tissue engineering purposes, but evidence of stem cell behavior on different compositions (various HA/β-TCP ratios) and physical features of BCPs is limited. We compared the adhesion, proliferation, viability and osteogenic potential of human mesenchymal stem cells (MSCs) on granular BCPs with equal HA/β-TCP ratio of diverse particle sizes and on porous blocks which had different chemical compositions. In addition, the osteogenic differentiation of MSCs was compared to adipose-derived (ADSC) and dental pulp (DPSC) stem cells, as well as to pre-osteoblasts on a particulate BCP. MSCs growing on granular BCPs demonstrated increased number as compared to MSCs growing on blocks. Cells proliferated to a greater extent on small granular BCPs, while large granular BCPs and blocks promoted cell differentiation. Surprisingly, the expression of genes involved in osteogenesis was upregulated in MSCs on bioceramics in basal medium which indicates that BCPs may have osteoinductive potential. This was confirmed with the upregulation of osteochondrogenic markers, at different time points, when stem cells from various tissues were grown on the BCP. This study demonstrates that BCPs, depending on their physical features and chemical composition, modulate stem cell behavior, and that stem cells from different origins are inherently distinct in their gene expression profile and can be triggered toward osteochondrogenic fate by BCPs.
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