ArticleProceedings of the National Academy of Sciences of the United States of America2015
Lemon-shaped halo archaeal virus His1 with uniform tail but variable capsid structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Two coinfecting archaeal viruses provide insights into virus-virus interactions.Communications biology · 2026Article
- Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus.Science advances · 2025Article
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- Conventional Electron Microscopy, Cryogenic Electron Microscopy, and Cryogenic Electron Tomography of Viruses.Sub-cellular biochemistry · 2024Review
- Archaeal virus entry and egress.microLife · 2024Review
- Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Three families of Asgard archaeal viruses identified in metagenome-assembled genomes.Nature microbiology · 2022Article
- Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.Cell · 2022Article
- Review
- Review
- New virus isolates from Italian hydrothermal environments underscore the biogeographic pattern in archaeal virus communities.The ISME journal · 2020Article
- Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.Nature communications · 2019Article
- Structure and assembly mechanism of virus-associated pyramids.Biophysical reviews · 2018Review
- Structural studies ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Review
- Article
- The PL6-Family Plasmids ofFrontiers in microbiology · 2018Article
- Diversity of dsDNA Viruses in a South African Hot Spring Assessed by Metagenomics and Microscopy.Viruses · 2017Article
- The enigmatic archaeal virosphere.Nature reviews. Microbiology · 2017Review
- Halophilic viruses with varying biochemical and biophysical properties are amenable to purification with asymmetrical flow field-flow fractionation.Extremophiles : life under extreme conditions · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Lemon-shaped viruses are common in nature but so far have been observed to infect only archaea. Due to their unusual shape, the structures of these viruses are challenging to study and therefore poorly characterized. Here, we have studied haloarchaeal virus His1 using cryo-electron tomography as well as biochemical dissociation. The virions have different sizes, but prove to be extremely stable under various biochemical treatments. Subtomogram averaging of the computationally extracted virions resolved a tail-like structure with a central tail hub density and six tail spikes. Inside the tail there are two cavities and a plug density that separates the tail hub from the interior genome. His1 most likely uses the tail spikes to anchor to host cells and the tail hub to eject the genome, analogous to classic tailed bacteriophages. Upon biochemical treatment that releases the genome, the lemon-shaped virion transforms into an empty tube. Such a dramatic transformation demonstrates that the capsid proteins are capable of undergoing substantial quaternary structural changes, which may occur at different stages of the virus life cycle.
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