ArticleProceedings of the National Academy of Sciences of the United States of America2015
Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
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- Chronotype, sleep quality, depression and pre-sleep rumination: A diary and actigraphy study.The European journal of neuroscience · 2024Article
- A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale.Scientific reports · 2023Article
- Article
- Induction of Fatigue by Specific Anthracycline Cancer Drugs through Disruption of the Circadian Pacemaker.Cancers · 2022Article
- A multi-level assessment of the bidirectional relationship between aging and the circadian clock.Journal of neurochemistry · 2021Review
- Group housing and social dominance hierarchy affect circadian activity patterns in mice.Royal Society open science · 2021Article
- Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model.Clocks & sleep · 2020Article
- From clock to functional pacemaker.The European journal of neuroscience · 2020Review
- Fractal Complexity of Daily Physical Activity Patterns Differs With Age Over the Life Span and Is Associated With Mortality in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Assessment of Fractal Characteristics of Locomotor Activity of Geriatric In-Patients With Alzheimer's Dementia.Frontiers in aging neuroscience · 2019Article
- Quantitative characterization of biological age and frailty based on locomotor activity records.Aging · 2018Article
- Fractal regulation and incident Alzheimer's disease in elderly individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice.Neurobiology of aging · 2018Article
- Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors.Chronobiology international · 2018Article
- How Old Is Your Brain? Slow-Wave Activity in Non-rapid-eye-movement Sleep as a Marker of Brain Rejuvenation After Long-Term Exercise in Mice.Frontiers in aging neuroscience · 2018Article
- Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation.Sleep · 2017Article
- Fractal Regulation in Temporal Activity Fluctuations: A Biomarker for Circadian Control and Beyond.JSM biomarkers · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In healthy humans and other animals, behavioral activity exhibits scale invariance over multiple timescales from minutes to 24 h, whereas in aging or diseased conditions, scale invariance is usually reduced significantly. Accordingly, scale invariance can be a potential marker for health. Given compelling indications that exercise is beneficial for mental and physical health, we tested to what extent a lack of exercise affects scale invariance in young and aged animals. We studied six or more mice in each of four age groups (0.5, 1, 1.5, and 2 y) and observed an age-related deterioration of scale invariance in activity fluctuations. We found that limiting the amount of exercise, by removing the running wheels, leads to loss of scale-invariant properties in all age groups. Remarkably, in both young and old animals a lack of exercise reduced the scale invariance in activity fluctuations to the same level. We next showed that scale invariance can be restored by returning the running wheels. Exercise during the active period also improved scale invariance during the resting period, suggesting that activity during the active phase may also be beneficial for the resting phase. Finally, our data showed that exercise had a stronger influence on scale invariance than the effect of age. The data suggest that exercise is beneficial as revealed by scale-invariant parameters and that, even in young animals, a lack of exercise leads to strong deterioration in these parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.