ArticleAnalytical chemistry2015
Voltammetric immunosensor assembled on carbon-pyrenyl nanostructures for clinical diagnosis of type of diabetes.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Nanobioelectrocatalysis Using Human Liver Microsomes and Cytochrome P450 Bactosomes: Pyrenyl-Nanocarbon Electrodes.ACS applied bio materials · 2024Article
- Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review.Sensors (Basel, Switzerland) · 2023Review
- Clinical Evaluation of a Novel Insulin Immunosensor.Journal of diabetes science and technology · 2023Article
- Development of a Novel Insulin Sensor for Clinical Decision-Making.Journal of diabetes science and technology · 2023Article
- Synthesis and grafting of diazonium tosylates for thermoplastic electrode immunosensors.Analytical methods : advancing methods and applications · 2021Article
- Biosensors and nanobiosensors for rapid detection of autoimmune diseases: a review.Mikrochimica acta · 2019Review
- Nanomaterials-based Electrochemical Immunosensors.Micromachines · 2019Review
- Electrochemical and surface plasmon insulin assays on clinical samples.The Analyst · 2018Review
- Measuring Ultra-low Levels of Nucleotide Biomarkers Using Quartz Crystal Microbalance and SPR Microarray Imaging Methods: A Comparative Analysis.Sensors and actuators. B, Chemical · 2017Article
- Pyrenyl carbon nanostructures for ultrasensitive measurements of formaldehyde in urine.Analytica chimica acta · 2017Article
- Combined covalent and noncovalent carboxylation of carbon nanotubes for sensitivity enhancement of clinical immunosensors.Chemical communications (Cambridge, England) · 2016Article
- Magnetic Optical Microarray Imager for Diagnosing Type of Diabetes in Clinical Blood Serum Samples.ACS sensors · 2016Article
- Stability, Scalability, and Reusability of a Volume Efficient Biocatalytic System Constructed on Magnetic Nanoparticles.Catalysis science & technology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Herein we report the first serum insulin voltammetric immunosensor for diagnosis of type 1 and type 2 diabetic disorders. The sensor is composed of multiwalled carbon nanotube-pyrenebutyric acid frameworks on edge plane pyrolytic graphite electrodes (PGE/MWNT/Py) to which an anti-insulin antibody was covalently attached. The detection of picomolar levels of serum insulin binding to the surface antibody was achieved by monitoring the decrease in voltammetric current signals of a redox probe taken in the electrolyte solution. This method offered a detection limit of 15 pM for free insulin present in serum. This detection limit was further lowered to 5 pM by designing serum insulin conjugates with poly(acrylic acid)-functionalized magnetite nanoparticles (100 nm hydrodynamic diameter) and detecting the binding of MNP-serum insulin conjugate to the surface insulin-antibody on PGE/MWNT/Py electrodes. When tested on real patient serum samples, the sensor accurately measured insulin levels. To our knowledge, this is the first report of a voltammetric immunosensor capable of both diagnosing and distinguishing the type of diabetes based on serum insulin levels in diabetic patients.
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