ArticlePloS one2015
Direct behavioral and neurophysiological evidence for retronasal olfaction in mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Establishment and characterization of a mouse model of cisplatin-induced olfactory aversion.Biochemistry and biophysics reports · 2026Article
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- Characterization of a novel oronasal-restricted nicotine vaping self-administration model in mice.Neuropharmacology · 2025Article
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- An intra-oral flavor detection task in freely moving mice.iScience · 2024Article
- Odor encoding by signals in the olfactory bulb.Journal of neurophysiology · 2023Article
- Multisensory integration of orally-sourced gustatory and olfactory inputs to the posterior piriform cortex in awake rats.The Journal of physiology · 2023Article
- Odor mixture perception during flavor consumption in rats.Behavioral neuroscience · 2022Article
- Transfer of Odor Perception From the Retronasal to the Orthonasal Pathway.Chemical senses · 2021Article
- Article
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- Retronasal Odor Perception Requires Taste Cortex, but Orthonasal Does Not.Current biology : CB · 2019Article
- Single-neuron responses to intraoral delivery of odor solutions in primary olfactory and gustatory cortex.Journal of neurophysiology · 2017Article
- Processing of Intraoral Olfactory and Gustatory Signals in the Gustatory Cortex of Awake Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A role for lung retention in the sense of retronasal smell.Chemosensory perception · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The neuroscience of flavor perception is hence becoming increasingly important to understand food flavor perception that guides food selection, ingestion and appreciation. We recently provided evidence that rats can use the retronasal mode of olfaction, an essential element of human flavor perception. We showed that in rats, like humans, odors can acquire a taste. We and others also defined how the input of the olfactory bulb (OB) -not functionally imageable in humans- codes retronasal smell in anesthetized rat. The powerful awake transgenic mouse, however, would be a valuable additional model in the study of flavor neuroscience. We used a go/no-go behavioral task to test the mouse's ability to detect and discriminate the retronasal odor amyl acetate. In this paradigm a tasteless aqueous odor solution was licked by water-restricted head-fixed mice from a lick spout. Orthonasal contamination was avoided. The retronasal odor was successfully discriminated by mice against pure distilled water in a concentration-dependent manner. Bulbectomy removed the mice's ability to discriminate the retronasal odor but not tastants. The OB showed robust optical calcium responses to retronasal odorants in these awake mice. These results suggest that mice, like rats, are capable of smelling retronasally. This direct neuro-behavioral evidence establishes the mouse as a useful additional animal model for flavor research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.