Evidence map›Paper›PMID 25674981›Full record

ArticleCell host & microbe2015

HSV cheats the executioner.

Karen L Mossman, Sandra K Weller

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling.Frontiers in cell and developmental biology · 2020
    Article
  2. Article
  3. RIPK3 promotes adenovirus type 5 activity.Cell death & disease · 2017
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Karen L MossmanDepartments of Biochemistry and Biomedical Sciences and Pathology and Molecular Medicine, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
Sandra K WellerDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: weller@uchc.edu.
McMaster University · CAUConn Health · US

Funding

GENETICS OF HSV DNA REPLICATIONR01AI021747 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WELLER, SANDRA K, WRIGHT, DENNIS L. · 1985 to 2024
$9.9M
Canadian Institutes of Health ResearchNIAID NIH HHS R01 AI021747NIAID NIH HHS R01 AI-21747
6 · The paper itself

Abstract

In this issue of Cell Host & Microbe, Huang et al. (2015) and Guo et al. (2015), along with recent work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in either inducing or preventing necroptosis, depending on the host species. This evolutionary twist underscores the importance of selective pressure in virus-host relationships.

Indexed as

AnimalsHost-Pathogen InteractionsHumansMaleProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesViral ProteinsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesViral Proteins

Identifiers

PMID25674981
OpenAlexW1965257365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.