ArticleNeurophotonics2014
Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography.
Article in Neurophotonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Optical attenuation coefficient decorrelation-based optical coherence tomography angiography for microvascular evaluation of Alzheimer's disease on mice.Neurophotonics · 2025Article
- Attenuation coefficient as a tool to detect changes in the white matter of the rat brain caused by different types of gliomas and irradiation.Biomedical optics express · 2024Article
- Automatic renal carcinoma biopsy guidance using forward-viewing endoscopic optical coherence tomography and deep learning.Communications engineering · 2024Article
- Automatic renal carcinoma biopsy guidance using forward-viewing endoscopic optical coherence tomography and deep learning.Research square · 2023Article
- Article
- The neurosurgical benefit of contactlessFrontiers in oncology · 2023Article
- Nondestructive label-free detection of peritumoral white matter damage using cross-polarization optical coherence tomography.Frontiers in oncology · 2023Article
- Depth-resolved extraction of optical attenuation for glaucoma assessment in clinical settings: a pilot study.Biomedical optics express · 2022Article
- OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives.Diagnostics (Basel, Switzerland) · 2022Review
- Review
- Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography.Biomedical optics express · 2021Article
- Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient.Journal of biophotonics · 2021Article
- Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension.Journal of neurotrauma · 2021Article
- Robust, accurate depth-resolved attenuation characterization in optical coherence tomography.Biomedical optics express · 2020Article
- Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model.Biomedical optics express · 2019Article
- Cerebral edema detectionNeurophotonics · 2019Article
- Polarization-sensitive optical coherence elastography.Biomedical optics express · 2019Article
- Review of methods and applications of attenuation coefficient measurements with optical coherence tomography.Journal of biomedical optics · 2019Review
- LongitudinalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Monitoring Acute Stroke Progression: Multi-Parametric OCT Imaging of Cortical Perfusion, Flow, and Tissue Scattering in a Mouse Model of Permanent Focal Ischemia.IEEE transactions on medical imaging · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema in vivo. Three-dimensional imaging of an in vivo water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was calculated and cerebral blood flow was analyzed using Doppler OCT techniques. We found that the average attenuation coefficient in the cerebral cortex decreased over time as edema progressed. The initial decrease began within minutes of inducing cerebral edema and a maximum decrease of 8% was observed by the end of the experiment. Additionally, cerebral blood flow slowed during late-stage edema. Analysis of local regions revealed the same trend at various locations in the brain, consistent with the global nature of the cerebral edema model used in this study. These results demonstrate that OCT is capable of detecting in vivo optical changes occurring due to cerebral edema and highlights the potential of OCT for precise spatiotemporal detection of cerebral edema.
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