ArticleTranslational medicine @ UniSa
Role of immunoglobulins in neonatal sepsis.
Article in Translational medicine @ UniSa. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence of Premature Birth History Among Type 1 Diabetes Mellitus (T1D) Patients and Characteristics of Premature Born Children Who Develop T1D Compared With Those Who do Not
A Prospective Study to Analyze the Efficacy of IgM Rich Immunoglobulin as an Adjunct to Antibiotics in the Treatment of Bacterial Sepsis in Very Low Birth Weight Preterm Neonates
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Pentaglobin (immunoglobulin M-enriched immunoglobulin) as adjuvant therapy for premature and very low-birth-weight neonates with sepsis.Indian journal of pharmacologyTrial
- Implementation of a Shunt Insertion Protocol and Its Effect on Institutional Shunt Infection Rates.Cureus · 2025Article
- Risk factors for cerebrospinal fluid shunt infection in pediatrics: A meta-analysis.Surgical neurology international · 2025Article
- Insight Into Neonatal Sepsis: An Overview.Cureus · 2023Review
- Clinical efficacy of IgM-enriched immunoglobulin as adjunctive therapy in neonatal and pediatric sepsis: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life.Nutrients · 2020Review
- Re-Evaluating Biologic Pharmacotherapies that Target the Host Response during Sepsis.International journal of molecular sciences · 2019Review
- High-dose of intravenous immunoglobulin modulates immune tolerance in premature infants.BMC pediatrics · 2018Article
- Bacterial Etiology and Antibiotic Resistance Patterns in Neonatal Sepsis in Tehran during 2006-2014.Iranian journal of pathology · 2017Article
- The effect of polyclonal and monoclonal based antibodies as promising potential therapy for treatment of sepsis: A systematic review.New microbes and new infectionsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.
Indexed as
Identifiers
25674546PMC4309652W2280954932What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.