Evidence map›Paper›PMID 25674284›Full record

ArticleInternational journal of clinical and experimental pathology2014

Mammary carcinoma with osteoclast-like giant cells: a case report.

Alia Saeed Albawardi, Aktham Adnan Awwad, Saeeda Saleh Almarzooqi

Abstract readCase Reports
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Breast carcinomas with osteoclast-like giant cells: a comprehensive clinico-pathological and molecular portrait and evidence of RANK-L expression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Squamous cell carcinoma of lung associated with osteoclast-like giant cells: report of a case.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alia Saeed AlbawardiDepartment of Pathology, College of Medicine & Health Sciences Al Ain, United Arab Emirates ; Tawam Hospital Al Ain, United Arab Emirates.
Aktham Adnan AwwadTawam Hospital Al Ain, United Arab Emirates.
Saeeda Saleh AlmarzooqiDepartment of Pathology, College of Medicine & Health Sciences Al Ain, United Arab Emirates ; Tawam Hospital Al Ain, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammary carcinoma with osteoclast-like giant cells is rare, and comprises less that 2% of breast carcinoma cases. Herein, we present a case of a 45-year-old woman who underwent breast lumpectomy and sentinel lymph node biopsy for a solitary well defined breast tumor. Histological examination revealed an invasive tumor composed of ducts, small nests and cribriform formations intermixed with a prominent osteoclast like giant cell component. The background stroma is hemorrhagic with conspicuous hemosiderin deposition. The paper will outline the clinico-pathologic characteristic features of this uncommon subtype as well as the current understanding on the pathogenesis of the osteoclast-like giant cells. The invasive carcinoma and the osteoclast-like giant cells staining patterns using immunohistochemical stains for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, receptor activator of nuclear-kB, RANK ligand, and matrix metalloproteinase 1 are reported.

Indexed as

Biomarkers, TumorBreast NeoplasmsCarcinoma, Giant CellChemoradiotherapy, AdjuvantFemaleHumansImmunohistochemistryMastectomy, SegmentalMiddle AgedNeoplasm InvasivenessNeoplasm StagingOsteoclastsSentinel Lymph Node BiopsyTreatment OutcomeBiomarkers, Tumorestrogen receptor (ER)human epidermal growth factor receptor 2 (Her2/neu)Mammary carcinomamatrix metalloproteinase 1 (MMP1)osteoclast like giant cellsprogesterone receptor (PR)RANK ligand (RANKL) expressionreceptor activator of nuclear-kB expression (RANK)

Identifiers

PMID25674284
PMCPMC4313993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.