TNFAIP3 rs2230926 polymorphisms in rheumatoid arthritis of southern Chinese Han population: a case-control study.

Guifeng Hao, Yasong Li, Jinlin Liu, Mingyi Wo

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed, 1 pooled it

0.9field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.Oncotarget · 2017
Pooled it
No association of eight TNFAIP3 single nucleotide variants to rheumatoid arthritis in Mexicans.Molecular biology reports · 2022
Article
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).Frontiers in cellular and infection microbiology · 2020
Review
An Autoimmune Disease-Associated Risk Variant in theJournal of clinical microbiology · 2018
Article
rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.PloS one · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guifeng HaoDepartment of Rheumatology, Zhejiang Provencial People's Hospital Hangzhou 310014, Zhejiang, China.

Yasong LiDepartment of Rheumatology, Zhejiang Provencial People's Hospital Hangzhou 310014, Zhejiang, China.

Jinlin LiuDepartment of Clinical Laboratory, Zhejiang Provencial People's Hospital Hangzhou 310014, Zhejiang, China.

Mingyi WoDepartment of Clinical Laboratory, Zhejiang Provencial People's Hospital Hangzhou 310014, Zhejiang, China.

Zhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphism of tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been be related to various auto-immune diseases. Based on previous studies that the single nucleotide polymorphism (SNP) of rs2230926 was association with rheumatoid arthritis (RA) of Japanese, Caucasian population and the northern Chinese Han population, we tested the alleles and geno-type frequencies of rs2230926 in TNFAIP3 to investigate whether rs2230926 is susceptible to RA of southern Chinese Han population. In our case-control association study, 207 RA patients fulfilling the American College of Rheumatology (ACR) 1987 criteria were compared with 199 unrelated healthy subjects. After testing the alleles and genotype frequencies of rs2230926, the airwise linkage disequilibrium (LD) was computed and odd ration (OR) and 95% confidence intervals (95% CI) were used for evaluating the susceptibility to RA. The SNP of rs2230926 of the cases and control subjects were conformed to the Hardy-Weinberg equilibrium (P = 0.02257). The significantly statistical differences in alleles of T, G were founded in the cases and controls (P = 0.0027, OR 0.417, 95% CI 0.232-0.749); the genetic types of rs2230926 were associated with a susceptibility to RA, with OR 0.375 (95% CI 0.198-0.707, P = 0.0018). In the present study, our results indicated that the genetic polymorphism of rs2230926 in TNFAIP3 may be a susceptible factor conferring risk for RA in southern Chinese Han population.

Indexed as

AdultAgedArthritis, RheumatoidAsian PeopleCase-Control StudiesDNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedNuclear ProteinsPolymorphism, Single NucleotideReverse Transcriptase Polymerase Chain ReactionDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsNuclear ProteinsTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3Rheumatoid arthritissingle nucleotide polymorphismTNFAIP3

Identifiers

PMID25674272

PMCPMC4314011

OpenAlexW2407286931

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.