ArticleInternational journal of clinical and experimental pathology2014
Biochemical changes of oxidative stress in premature ovarian insufficiency induced by tripterygium glycosides.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Evaluation of the protective effect of melatonin on oocyte, embryo and ovarian tissue parameters in female mice exposed to acetamiprid.JBRA assisted reproduction · 2023Article
- Association of Coenzyme Q10 with Premature Ovarian Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Review
- The Technique of Phacoemulsification and Intraocular Lens Implantation in Subluxated Cataract Surgery.Stem cells international · 2022Article
- Bushen Culuan Decoction Ameliorates Premature Ovarian Insufficiency by Acting on the Nrf2/ARE Signaling Pathway to Alleviate Oxidative Stress.Frontiers in pharmacology · 2022Article
- Moxibustion improves ovarian function based on the regulation of the androgen balance.Experimental and therapeutic medicine · 2021Article
- The Emerging Key Role of Klotho in the Hypothalamus-Pituitary-Ovarian Axis.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Successful pregnancy with tripterygium glycoside-induced premature ovarian insufficiency: a case report.The Journal of international medical research · 2019Article
- Synergistic oxidative impact of aluminum chloride and sodium fluoride exposure during early stages of brain development in the rat.Environmental science and pollution research international · 2019Article
- Melatonin protects premature ovarian insufficiency induced by tripterygium glycosides: role of SIRT1.American journal of translational research · 2017Article
- Reply to the letter by Ali Kagan Coskun et al.: The effects of oxidative stress following ischemia-reperfusion injury.International urology and nephrology · 2016Article
- Article
- Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults.Preventive nutrition and food science · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature ovarian insufficiency (POI) is one of clinical manifestations of ovarian damage. This study is to evaluate biochemical changes of oxidative stress in POI induced by tripterygium glycosides (TG) via subcutaneous injection. 24 female KM mice were assigned to two groups: control group and TG group. The mice in TG group were subjected to 50 mg.kg(-1).d(-1) TG for 35 days, while these in control group were fed with parallel volume of sterile water. Blood samples were separately obtained in day 15, 22, 29, 36 and 43. Ovarian histopathological changes were determined when finished the administration and observed under optical microscope. Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and anti-mullerian hormone (AMH) and ovarian homogenates levels of MDA, SOD, GSH-Px and AMH were assessed by ELISA. AMH expression in the ovaries was analyzed by immunohistochemistry. Compared with control group, the results in TG group showed a significant reduction of serum levels of SOD and GSH-Px in day 15, 22, 29, 43 and increase of MDA in day 22, 36. They also presented decreased SOD and GSH-Px levels and increased MDA level in ovarian homogenates. Our data suggested that oxidative stress was involved in POI and might be the potential pathogenesis of POI induced by TG.
Indexed as
Identifiers
25674255PMC4313959W2295740380What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.