Evidence map›Paper›PMID 25674199›Full record

ReviewInternational journal of clinical and experimental pathology2014

Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.

Chang Liu, Guohong Cui, Meiping Zhu, Xiangping Kang, Haidong Guo

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chang LiuSchool of Basic Medicine, Shanghai University of Traditional Chinese Medicine Shanghai, China.
Guohong CuiDepartment of Neurology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Meiping ZhuDepartment of Gastroenterology, Shanghai Shuguang Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
Xiangping KangDepartment of Biochemistry, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine Shanghai, China.
Haidong GuoDepartment of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines secreted by astrocytes play multiple roles in the pathology of Alzheimer's disease, a chronic inflammation disorder of central nervous system. The level of chemokines in serum, cerebrospinal fluid and brain tissue and their receptors both significantly changed in patients with Alzheimer's disease. In this review, we briefly summarized the involvement of astrocytes and chemokines in Alzheimer's disease, and the role of chemokine/chemokine receptors in the occurrence and development of Alzheimer's disease. Clarification of the involvement of chemokines and their receptors, such as MCP-1/CCR2, fractalkine/CX3CR1, SDF-1α/CXCR4, MIP-1α/CCR5, IP-10/CXCR3, IL-8/CXCR1, CXCR2, and RANTES/CCR1, CCR3, CCR5, will provide a new strategy and more specific targets for the treatment of Alzheimer's disease.

Indexed as

Alzheimer DiseaseAnimalsAstrocytesChemokinesHumansInflammationReceptors, ChemokineChemokinesReceptors, ChemokineAlzheimer’s diseaseastrocyteschemokine receptorschemokinesinflammation

Identifiers

PMID25674199
PMCPMC4314046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.