ArticleFrontiers in plant science2014
Transcriptome and metabolome analysis of plant sulfate starvation and resupply provides novel information on transcriptional regulation of metabolism associated with sulfur, nitrogen and phosphorus nutritional responses in Arabidopsis.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 110 citations in OpenAlex.
- A factorial multi-layer analysis reveals non-additive sulfur-iron interactions shaping metabolic and transcriptional responses in durum wheat.The New phytologist · 2026Article
- Methylthioadenosine-driven rewiring of sulfur assimilation lowers the methyl index and fertility in Arabidopsis.Journal of experimental botany · 2026Article
- Hidden players in plant response to sulfur deficit and beyond: insights into the function of the proteins Sulfur Deficiency Induced and Response to Low Sulfur.Journal of experimental botany · 2026Review
- Circadian clock-related transcription factors Reveille 1 and Reveille 8 regulate the O-acetylserine cluster genes and sulfur homeostasis.Plant physiology · 2026Article
- The primary nitrate response TGA1 and TGA4 transcription factors are negative regulators of sulfate uptake and metabolism.Plant physiology · 2026Article
- Functional Genomics of Sulfur Metabolism in Rice: Insights From Transgenic and MicroRNA-Based Strategies.Plant direct · 2026Review
- Sulfate starvation response modules connect sulfur metabolism to photorespiration and photosynthesis.The Plant journal : for cell and molecular biology · 2026Article
- Sulfate Deficiency-Responsive MicroRNAs in Tomato Uncover an Expanded and Functionally Integrated Regulatory Network.International journal of molecular sciences · 2025Article
- Non-Targeted Metabolome Analysis with Low-Dose Selenate-TreatedPlants (Basel, Switzerland) · 2025Article
- Development of plant extracts as substrates for untargeted transporter substrate identification inFrontiers in plant science · 2025Article
- A Multi-Omics View of Maize's (International journal of molecular sciences · 2024Article
- Dynamics of mRNA fate during light stress and recovery: from transcription to stability and translation.The Plant journal : for cell and molecular biology · 2024Article
- Genome-wide identification and analysis of the GGCT gene family in wheat.BMC genomics · 2024Article
- New insights into the regulation of plant metabolism by O-acetylserine: sulfate and beyond.Journal of experimental botany · 2023Article
- The SLIM1 transcription factor affects sugar signaling during sulfur deficiency in Arabidopsis.Journal of experimental botany · 2022Article
- Transcriptome and metabolome profiling of interspecific CSSLs reveals general and specific mechanisms of drought resistance in cotton.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Glutathione degradation activity of γ-glutamyl peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis.The Plant journal : for cell and molecular biology · 2022Article
- Article
- Assessing the Effect of Silicon Supply on Root Sulfur Uptake in S-Fed and S-DeprivedPlants (Basel, Switzerland) · 2022Article
- Evolutionary and Gene Expression Analyses Reveal New Insights into the Role ofPlants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfur is an essential macronutrient for plant growth and development. Reaching a thorough understanding of the molecular basis for changes in plant metabolism depending on the sulfur-nutritional status at the systems level will advance our basic knowledge and help target future crop improvement. Although the transcriptional responses induced by sulfate starvation have been studied in the past, knowledge of the regulation of sulfur metabolism is still fragmentary. This work focuses on the discovery of candidates for regulatory genes such as transcription factors (TFs) using 'omics technologies. For this purpose a short term sulfate-starvation/re-supply approach was used. ATH1 microarray studies and metabolite determinations yielded 21 TFs which responded more than 2-fold at the transcriptional level to sulfate starvation. Categorization by response behaviors under sulfate-starvation/re-supply and other nutrient starvations such as nitrate and phosphate allowed determination of whether the TF genes are specific for or common between distinct mineral nutrient depletions. Extending this co-behavior analysis to the whole transcriptome data set enabled prediction of putative downstream genes. Additionally, combinations of transcriptome and metabolome data allowed identification of relationships between TFs and downstream responses, namely, expression changes in biosynthetic genes and subsequent metabolic responses. Effect chains on glucosinolate and polyamine biosynthesis are discussed in detail. The knowledge gained from this study provides a blueprint for an integrated analysis of transcriptomics and metabolomics and application for the identification of uncharacterized genes.
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