ArticleJournal of pain research2015
Fibromyalgia patients have reduced hippocampal volume compared with healthy controls.
Article in Journal of pain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Salivary cortisol is associated with cognitive changes in patients with fibromyalgia.Scientific reports · 2021Trial
- Benefits of resistance exercise in lean women with fibromyalgia: involvement of IGF-1 and leptin.BMC musculoskeletal disorders · 2017Trial
- Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns.Nutrients · 2026Article
- Fibromyalgia and Risk of Alzheimer's DiseaseRelated Dementia: A Nationwide Bidirectional Case-Control Study.Geriatrics (Basel, Switzerland) · 2026Article
- Multivariate Pattern Analysis Identifies Potential Intertrial Resting-State EEG Biomarkers in Fibromyalgia.The European journal of neuroscience · 2026Article
- Pituitary Gland Volume in Fibromyalgia Syndrome: A Case-Control Volumetric MRI Study.Journal of pain research · 2026Article
- Hyperbaric Oxygen Therapy as a Therapeutic Option for Patients with Fibromyalgia.Current rheumatology reviews · 2026Review
- Coenzyme Q10 Ameliorates Fibromyalgia-like Symptoms and Cognitive Deficits by Enhancing Hippocampal PGC-1α/FNDC5/BDNF Pathway in Reserpine-Treated Rats.Molecular neurobiology · 2025Article
- Cross-sectional relationships between spinal cord gray matter volume and pain in individuals with fibromyalgia and opioid use.Scientific reports · 2025Article
- Milnacipran and Vanillin Alleviate Fibromyalgia-Associated Depression in Reserpine-Induced Rat Model: Role of Wnt/β-Catenin Signaling.Molecular neurobiology · 2025Article
- Article
- Preliminary investigation of the interactive role of physiological arousal and insomnia complaints in gray matter volume alterations in chronic widespread pain.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Atrophy patterns in hippocampal subregions and their relationship with cognitive function in fibromyalgia patients with mild cognitive impairment.Frontiers in neuroscience · 2024Article
- Personality systems interactions theory: an integrative framework complementing the study of the motivational and volitional dynamics underlying adjustment to chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Diet and Lifestyle Modifications for Fibromyalgia.Current rheumatology reviews · 2024Review
- Impact of being physically active on the brain electrocortical activity, brain volumetry and performance in the Stroop color and word test in women with fibromyalgia.Scientific reports · 2022Article
- Longitudinal associations of physical fitness and affect with depression, anxiety and life satisfaction in adult women with fibromyalgia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveFibromyalgia patients frequently report cognitive abnormalities. As the hippocampus plays an important role in learning and memory, we determined whether individuals with fibromyalgia had smaller hippocampal volume compared with healthy control participants.
methodsT1-weighted structural magnetic resonance imaging (MRI) scans were acquired from 40 female participants with fibromyalgia and 22 female healthy controls. The volume of the hippocampus was estimated using the software FreeSurfer. An analysis of covariance model controlling for potentially confounding factors of age, whole brain size, MRI signal quality, and Beck Depression Inventory scores were used to determine significant group differences.
resultsFibromyalgia participants had significantly smaller hippocampi in both left (F[1,56]=4.55, P=0.037, η (2) p=0.08) and right hemispheres (F[1,56]=5.89, P=0.019, η (2) p=0.10). No significant effect of depression was observed in either left or right hemisphere hippocampal volume (P=0.813 and P=0.811, respectively). DISCUSSION: Potential mechanisms for reduced hippocampal volume in fibromyalgia include abnormal glutamate excitatory neurotransmission and glucocorticoid dysfunction; these factors can lead to neuronal atrophy, through excitotoxicity, and disrupt neurogenesis in the hippocampus. Hippocampal atrophy may play a role in memory and cognitive complaints among fibromyalgia patients.
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Registered trials
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