ArticleInternational journal of chronic obstructive pulmonary disease2015
Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease.
Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationship between obstructive sleep apnea-hypopnea syndrome and osteoporosis adults: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Association between sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Objectively measured sleep parameters and bone health: results from the Human Phenotype Project (HPP) cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Sleep-Disordered Breathing and Decreased Bone Mineral Density: Masking Effects of Body Mass Index.Obesity facts · 2026Article
- Obstructive Sleep Apnoea and Risk of Fragility Fracture in Patients With Type 2 Diabetes: A Population-Based Retrospective Cohort Study.Endocrinology, diabetes & metabolism · 2025Article
- Association between obstructive sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Sleep and biological rhythms · 2024Article
- Osteoporosis in a Rat Model Co-Exposed to Cigarette Smoke and Intermittent Hypoxia.International journal of chronic obstructive pulmonary disease · 2020Article
- Oxygen desaturation during the 6-min walk test as a risk for osteoporosis in non-cystic fibrosis bronchiectasis.BMC pulmonary medicine · 2019Article
- Obstructive sleep apnea and hormones - a novel insight.Archives of medical science : AMS · 2017Article
- Increased fragility fracture risk in Korean women who snore: a 10-year population-based prospective cohort study.BMC musculoskeletal disorders · 2017Article
- Association Between Obstructive Sleep Apnea and Osteoporosis: A Systematic Review and Meta-Analysis.International journal of endocrinology and metabolism · 2016Review
- Obstructive Sleep Apnea is Not Associated with an Increased Risk of Osteoporosis: a Systematic Review and Meta-Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Article
- Obstructive Sleep Apnea and Osteoporosis Risk.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is an important issue for patients with chronic obstructive pulmonary disease (COPD). Worse systemic inflammation and reduced exercise capacity have been reported in COPD patients with obstructive sleep apnea (OSA), implying that OSA may be an independent factor for osteoporosis in COPD patients.
methodsA total of 66 patients with bone mineral density (BMD) and polysomnography results from a previous COPD cohort (January 2008 to January 2013) were retrospectively enrolled. Clinical characteristics such as medication, pulmonary function, BMD, and results of polysomnography were analyzed.
resultsThe BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045). In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were significantly associated with BMD. After multivariate linear regression analysis, the ODI was still an independent factor for BMD. In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity.
conclusionOSA may be an independent factor for BMD in patients with COPD, which implies a possible vicious cycle takes place in these patients.
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