Evidence map›Paper›PMID 25673979›Full record

Trial reportClinical interventions in aging2015

Mécano-Stimulation™ of the skin improves sagging score and induces beneficial functional modification of the fibroblasts: clinical, biological, and histological evaluations.

Philippe Humbert, Ferial Fanian, Thomas Lihoreau, Adeline Jeudy, Ahmed Elkhyat, Sophie Robin, Carol Courderot-Masuyer, Hélène Tauzin, Christine Lafforgue, Marek Haftek

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical interventions in aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07418060 (Randomized, Multicentre Study Evaluating the Impact of Pre-habilitation Using Physiotherapy and Mechanical Stimulation on Shoulder Pain and Mobility in Patients Undergoing Breast Reconstruction Using a Latissimus Dorsi Flap), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07418060 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Randomized, Multicentre Study Evaluating the Impact of Pre-habilitation Using Physiotherapy and Mechanical Stimulation on Shoulder Pain and Mobility in Patients Undergoing Breast Reconstruction Using a Latissimus Dorsi Flap

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2026 to 2029Enrolled72ConditionsBreast Cancer, Physiotherapy, Breast Reconstruction, Latissimus Dorsi FlapArmsPrehabilitation with physiotherapy including mechanostimulation, No Prehabilitation with physiotherapy including mechanostimulation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Biomaterials to Mimic and Heal Connective Tissues.Advanced materials (Deerfield Beach, Fla.) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Philippe HumbertResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Ferial FanianResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Thomas LihoreauResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Adeline JeudyResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Ahmed ElkhyatResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Sophie RobinSARL BIOEXIGENCE, Besançon, France.
Carol Courderot-MasuyerSARL BIOEXIGENCE, Besançon, France.
Hélène TauzinSARL BIOEXIGENCE, Besançon, France.
Christine LafforgueResearch and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC 1431), Besançon University Hospital, Besançon, France ; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France ; Dermopharmacology and Cosmetology Unit, University of Paris Sud, France.
Marek HaftekUniversity of Lyon 1, EA4169, Experimental, clinical and therapeutic aspects of the skin barrier function, INSERM US7 - CNRS UMS3453, Lyon, France.
Université de franche-comté · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLoss of mechanical tension appears to be the major factor underlying decreased collagen synthesis in aged skin. Numerous in vitro studies have shown the impact of mechanical forces on fibroblasts through mechanotransduction, which consists of the conversion of mechanical signals to biochemical responses. Such responses are characterized by the modulation of gene expression coding not only for extracellular matrix components (collagens, elastin, etc.) but also for degradation enzymes (matrix metalloproteinases [MMPs]) and their inhibitors (tissue inhibitors of metalloproteinases [TIMPs]). A new device providing a mechanical stimulation of the cutaneous and subcutaneous tissue has been used in a simple, blinded, controlled, and randomized study. MATERIALS AND

methodsThirty subjects (aged between 35 years and 50 years), with clinical signs of skin sagging, were randomly assigned to have a treatment on hemiface. After a total of 24 sessions with Mécano-Stimulation™, biopsies were performed on the treated side and control area for in vitro analysis (dosage of hyaluronic acid, elastin, type I collagen, MMP9; equivalent dermis retraction; GlaSbox(®); n=10) and electron microscopy (n=10). Furthermore, before and after the treatment, clinical evaluations and self-assessment questionnaire were done.

resultsIn vitro analysis showed increases in hyaluronic acid, elastin, type I collagen, and MMP9 content along with an improvement of the migratory capacity of the fibroblasts on the treated side. Electron microscopy evaluations showed a clear dermal remodeling in relation with the activation of fibroblast activity. A significant improvement of different clinical signs associated with skin aging and the satisfaction of the subjects were observed, correlated with an improvement of the sagging cheek.

conclusionMécano-Stimulation is a noninvasive and safe technique delivered by flaps microbeats at various frequencies, which can significantly improve the skin trophicity. Results observed with objective measurements, ie, in vitro assessments and electron microscopy, confirm the firming and restructuring effect clinically observed.

Indexed as

FaceSkin AgingAdultCollagen Type ICosmetic TechniquesDouble-Blind MethodElastinExtracellular MatrixFemaleFibroblastsHumansHyaluronic AcidMaleMatrix Metalloproteinase 9Middle AgedCollagen Type IElastinHyaluronic AcidMatrix Metalloproteinase 9fibroblast synthesismechanical stimulationskin rejuvenationskin sagging

Identifiers

PMID25673979
PMCPMC4321566
OpenAlexW2084154500

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.