Conestat alfa (ruconest): first recombinant c1 esterase inhibitor for the treatment of acute attacks in patients with hereditary angioedema.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Genetically Modified and Gene-Edited Organisms-Objectives, Public Perception and Applications.Biology · 2026
   Review
2. Roles of the Complement System in Peripheral Nerve Injury and Repair.Bioengineering (Basel, Switzerland) · 2026
   Review
3. Bradykinin-induced angioedema in the emergency department.International journal of emergency medicine · 2022
   Review
4. Targeting complement cascade: an alternative strategy for COVID-19.3 Biotech · 2020
   Review
5. Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target.Frontiers in immunology · 2020
   Review
6. Self-Management Plans in Patients with Hereditary Angioedema: Strategies, Outcomes and Integration into Clinical Care.Journal of asthma and allergy · 2020
   Review
7. Breakthroughs in hereditary angioedema management: a systematic review of approved drugs and those under research.Drugs in context · 2019
   Review
8. Pharmaceutical Machine Learning: Virtual High-Throughput Screens Identifying Promising and Economical Small Molecule Inhibitors of Complement Factor C1s.Biomolecules · 2018
   Article
9. Angioedema in the emergency department: a practical guide to differential diagnosis and management.International journal of emergency medicine · 2017
   Review
10. Evaluation of staging criteria for disposition and airway intervention in emergency department angioedema patients.Acute medicine & surgery
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract