Evidence map›Paper›PMID 25673912›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2015

Experimental infection of meadow voles (Microtus pennsylvanicus) with sheep scrapie.

Christina M Carlson, Jay R Schneider, Joel A Pedersen, Dennis M Heisey, Christopher J Johnson

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Assisted reproductive technologies inReproductive medicine and biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christina M CarlsonUS Geological Survey (USGS) National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711-6223, USA (Carlson, Schneider, Heisey, Johnson); Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA (Carlson, Pedersen); Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA (Pedersen).
Jay R SchneiderUS Geological Survey (USGS) National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711-6223, USA (Carlson, Schneider, Heisey, Johnson); Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA (Carlson, Pedersen); Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA (Pedersen).
Joel A PedersenUS Geological Survey (USGS) National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711-6223, USA (Carlson, Schneider, Heisey, Johnson); Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA (Carlson, Pedersen); Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA (Pedersen).
Dennis M HeiseyUS Geological Survey (USGS) National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711-6223, USA (Carlson, Schneider, Heisey, Johnson); Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA (Carlson, Pedersen); Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA (Pedersen).
Christopher J JohnsonUS Geological Survey (USGS) National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711-6223, USA (Carlson, Schneider, Heisey, Johnson); Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA (Carlson, Pedersen); Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA (Pedersen).
National Wildlife Health Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meadow voles (Microtus pennsylvanicus) are permissive to chronic wasting disease (CWD) infection, but their susceptibility to other transmissible spongiform encephalopathies (TSEs) is poorly characterized. In this initial study, we intracerebrally challenged 6 meadow voles with 2 isolates of sheep scrapie. Three meadow voles acquired a TSE after the scrapie challenge and an extended incubation period. The glycoform profile of proteinase K-resistant prion protein (PrP(res)) in scrapie-sick voles remained similar to the sheep inocula, but differed from that of voles clinically affected by CWD. Vacuolization patterns and disease-associated prion protein (PrP(Sc)) deposition were generally similar in all scrapie-affected voles, except in the hippocampus, where PrP(Sc) staining varied markedly among the animals. Our results demonstrate that meadow voles can acquire a TSE after intracerebral scrapie challenge and that this species could therefore prove useful for characterizing scrapie isolates.

Indexed as

Disease Models, AnimalAnimalsArvicolinaeBiomarkersBrainPhenotypePrionsScrapieSheepWasting Disease, ChronicBiomarkersPrions

Identifiers

PMID25673912
PMCPMC4283237
OpenAlexW2273138375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.