ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Norepinephrine is necessary for experience-dependent plasticity in the developing mouse auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity.eLife · 2023Article
- Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.Scientific reports · 2023Article
- From pupil to the brain: New insights for studying cortical plasticity through pupillometry.Frontiers in neural circuits · 2023Review
- Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Nigrostriatal dopamine pathway regulates auditory discrimination behavior.Nature communications · 2022Article
- Neuromodulation and Individuality.Frontiers in behavioral neuroscience · 2021Review
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance.eLife · 2020Article
- From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.Seminars in cell & developmental biology · 2019Review
- β-adrenergic modulation of discrimination learning and memory in the auditory cortex.The European journal of neuroscience · 2019Article
- Noradrenergic Modulation on Dopaminergic Neurons.Neurotoxicity research · 2018Review
- Familiarity with social sounds alters c-Fos expression in auditory cortex and interacts with estradiol in locus coeruleus.Hearing research · 2018Article
- Developmental auditory exposure shapes responses of catecholaminergic neurons to socially-modulated song.Scientific reports · 2018Article
- Adults with autism overestimate the volatility of the sensory environment.Nature neuroscience · 2017Article
- Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery.Frontiers in psychology · 2017Article
- Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity.Journal of neurophysiology · 2016Article
- Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.Journal of neurophysiology · 2015Article
- Norepinephrine Modulates Coding of Complex Vocalizations in the Songbird Auditory Cortex Independent of Local Neuroestrogen Synthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Selective Increase of Auditory Cortico-Striatal Coherence during Auditory-Cued Go/NoGo Discrimination Learning.Frontiers in behavioral neuroscience · 2015Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Critical periods are developmental windows during which the stimuli an animal encounters can reshape response properties in the affected system to a profound degree. Despite this window's importance, the neural mechanisms that regulate it are not completely understood. Pioneering studies in visual cortex initially indicated that norepinephrine (NE) permits ocular dominance column plasticity during the critical period, but later research has suggested otherwise. More recent work implicating NE in experience-dependent plasticity in the adult auditory cortex led us to re-examine the role of NE in critical period plasticity. Here, we exposed dopamine β-hydroxylase knock-out (Dbh(-/-)) mice, which lack NE completely from birth, to a biased acoustic environment during the auditory cortical critical period. This manipulation led to a redistribution of best frequencies (BFs) across auditory cortex in our control mice, consistent with prior work. By contrast, Dbh(-/-) mice failed to exhibit the expected redistribution of BFs, even though NE-deficient and NE-competent mice showed comparable auditory cortical organization when reared in a quiet colony environment. These data suggest that while intrinsic tonotopic patterning of auditory cortical circuitry occurs independently from NE, NE is required for critical period plasticity in auditory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.