ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Responses to conflicting stimuli in a simple stimulus-response pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Non-synaptic Plasticity in Leech Touch Cells.Frontiers in physiology · 2019Article
- Effects of Touch Location and Intensity on Interneurons of the Leech Local Bend Network.Scientific reports · 2018Article
- Higher Network Activity Induced by Tactile Compared to Electrical Stimulation of Leech Mechanoreceptors.Frontiers in physiology · 2018Article
- A double-sided microscope to realize whole-ganglion imaging of membrane potential in the medicinal leech.eLife · 2017Article
- Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech.Frontiers in physiology · 2016Article
- Optically transparent multi-suction electrode arrays.Frontiers in neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "local bend response" of the medicinal leech (Hirudo verbana) is a stimulus-response pathway that enables the animal to bend away from a pressure stimulus applied anywhere along its body. The neuronal circuitry that supports this behavior has been well described, and its responses to individual stimuli are understood in quantitative detail. We probed the local bend system with pairs of electrical stimuli to sensory neurons that could not logically be interpreted as a single touch to the body wall and used multiple suction electrodes to record simultaneously the responses in large numbers of motor neurons. In all cases, responses lasted much longer than the stimuli that triggered them, implying the presence of some form of positive feedback loop to sustain the response. When stimuli were delivered simultaneously, the resulting motor neuron output could be described as an evenly weighted linear combination of the responses to the constituent stimuli. However, when stimuli were delivered sequentially, the second stimulus had greater impact on the motor neuron output, implying that the positive feedback in the system is not strong enough to render it immune to further input.
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Registered trials
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