ArticleJournal of clinical microbiology2015
A signal-to-cutoff ratio in the Abbott architect HIV Ag/Ab Combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Anti-HIV Serological Profiles and Concordance of Chemiluminescent Immunoassay Screening With a Supplemental Rapid Test Among Blood Donors in Côte d'Ivoire.Journal of immunology research · 2026Article
- Article
- Navigating false positive HIV test results: a case report.ASM case reports · 2025Article
- HIV testing algorithm using fourth generation reagents reduces the false positive rate of screening tests.Scientific reports · 2025Article
- Using signal-to-cutoff ratios of HIV screening assay to predict HIV infection.BMC infectious diseases · 2023Article
- Risk Factors of Transfusion Transmissible Infections among Blood Donors at Karongi Regional Centre for Blood Transfusion in Rwanda.Rwanda journal of medicine and health sciences · 2023Article
- Article
- Utility of the Signal-to-Cutoff Ratio and Antigen Index from Fourth- and Fifth-Generation HIV-1/HIV-2 Antigen/Antibody Assays for the Diagnosis of Acute HIV Infection: Applicability for Real-Time Use for Immediate Initiation of Antiretroviral Therapy.Journal of clinical microbiology · 2022Article
- Am I Positive? Improving Human Immunodeficiency Virus Testing in the Era of Preexposure Prophylaxis and Immediate Antiretroviral Therapy Using Machine Learning.Open forum infectious diseases · 2022Article
- An Analysis of Predictive Sample-to-Cutoff Index for HIV Infection Confirmation Using Elecsys® HIV Combi PT Assay.International journal of clinical practice · 2022Article
- Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center.Data in brief · 2021Article
- Novel Criteria for Diagnosing Acute and Early Human Immunodeficiency Virus Infection in a Multinational Study of Early Antiretroviral Therapy Initiation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- A method to alleviate false-positive results of the Elecsys HIV combi PT assay.Scientific reports · 2021Article
- Poststudy Point-of-Care Oral Fluid Testing in Human Immunodeficiency Virus-1 Vaccinees.Open forum infectious diseases · 2021Article
- Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population.Data in brief · 2020Article
- Different Re-centrifugation Conditions for Infectious Disease Screening Using the Abbott I2000.Current medical science · 2020Article
- High level of HIV false positives using EIA-based algorithm in survey: Importance of confirmatory testing.PloS one · 2020Article
- Sample-to-cutoff ratios using Architect HIV Ag/Ab Combo: The influence with the results of supplemental tests and optimal cutoff value to predict HIV infection.Journal of clinical laboratory analysis · 2019Article
- HIV serology signal-to-cutoff ratio as a rapid method to predict confirmation of HIV infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Positive or Not, That Is the Question: HIV Testing for Individuals on Pre-exposure Prophylaxis.Journal of acquired immune deficiency syndromes (1999) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.