ArticleJournal of neurophysiology2015
Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Effects of meditation practice on spontaneous eyeblink rate.Psychophysiology · 2016Trial
- Spontaneous eye blink-based machine learning for tracking clinical fluctuations in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Article
- Effects of Deep Brain Stimulation on Eye Movements and Vestibular Function.Frontiers in neurology · 2018Review
- Eyelid Dysfunction in Neurodegenerative, Neurogenetic, and Neurometabolic Disease.Frontiers in neurology · 2017Review
- Translational neurophysiology of Parkinson's disease: can't blink on an eye blink.Journal of neurophysiology · 2015Article
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3 authors at 2 institutions in 1 country.
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Abstract
Parkinson's disease (PD) patients and the 6-hydroxydopamine (6-OHDA) lesioned rat model share blink abnormalities. In view of the evolutionarily conserved organization of blinking, characterization of blink reflex circuits in rodents may elucidate the neural mechanisms of PD reflex abnormalities. We examine the extent of this shared pattern of blink abnormalities by measuring blink reflex excitability, blink reflex plasticity, and spontaneous blinking in 6-OHDA lesioned rats. We also investigate whether 130-Hz subthalamic nucleus deep brain stimulation (STN DBS) affects blink abnormalities, as it does in PD patients. Like PD patients, 6-OHDA-lesioned rats exhibit reflex blink hyperexcitability, impaired blink plasticity, and a reduced spontaneous blink rate. At 130 Hz, but not 16 Hz, STN DBS eliminates reflex blink hyperexcitability and restores both short- and long-term blink plasticity. Replicating its lack of effect in PD patients, 130-Hz STN DBS does not reinstate a normal temporal pattern or rate to spontaneous blinking in 6-OHDA lesioned rats. These data show that the 6-OHDA lesioned rat is an ideal model system for investigating the neural bases of reflex abnormalities in PD and highlight the complexity of PD's effects on motor control, by showing that dopamine depletion does not affect all blink systems via the same neural mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.