Evidence map›Paper›PMID 25673738›Full record

ArticleJournal of neurophysiology2015

Transspinal direct current stimulation immediately modifies motor cortex sensorimotor maps.

Weiguo Song, Dennis Q Truong, Marom Bikson, John H Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Transneuronal Downregulation of the Premotor Cholinergic System After Corticospinal Tract Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weiguo SongDepartment of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York;
Dennis Q TruongDepartment of Biomedical Engineering, City College of the City University of New York, New York, New York; and.
Marom BiksonDepartment of Biomedical Engineering, City College of the City University of New York, New York, New York; and.
John H MartinDepartment of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York; Graduate Center of the City University of New York, New York, New York jmartin@ccny.cuny.edu.

Funding

Lesion and Activity Dependent Corticospinal Tract PlasticityR01NS064004 · NINDS · RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK D/B/A RF CUNY - CUNY SCHOOL OF MEDICINE · PI John H Martin · 2009 to 2026
$5.2M
NINDS NIH HHS 2R01NS064004NINDS NIH HHS R01 NS064004
6 · The paper itself

Abstract

Motor cortex (MCX) motor representation reorganization occurs after injury, learning, and different long-term stimulation paradigms. The neuromodulatory approach of transspinal direct current stimulation (tsDCS) has been used to promote evoked cortical motor responses. In the present study, we used cathodal tsDCS (c-tsDCS) of the rat cervical cord to determine if spinal cord activation can modify the MCX forelimb motor map. We used a finite-element method model based on coregistered high-resolution rat MRI and microcomputed tomography imaging data to predict spinal current density to target stimulation to the caudal cervical enlargement. We examined the effects of cathodal and anodal tsDCS on the H-reflex and c-tsDCS on responses evoked by intracortical microstimulation (ICMS). To determine if cervical c-tsDCS also modified MCX somatic sensory processing, we examined sensory evoked potentials (SEPs) produced by wrist electrical stimulation and induced changes in ongoing activity. Cervical c-tsDCS enhanced the H-reflex, and anodal depressed the H-reflex. Using cathodal stimulation to examine cortical effects, we found that cervical c-tsDCS immediately modified the forelimb MCX motor map, with decreased thresholds and an expanded area. c-tsDCS also increased SEP amplitude in the MCX. The magnitude of changes produced by c-tsDCS were greater on the motor than sensory response. Cervical c-tsDCS more strongly enhanced forelimb than hindlimb motor representation and had no effect on vibrissal representation. The finite-element model indicated current density localized to caudal cervical segments, informing forelimb motor selectivity. Our results suggest that c-tsDCS augments spinal excitability in a spatially selective manner and may improve voluntary motor function through MCX representational plasticity.

Indexed as

Adaptation, PhysiologicalAnimalsBrain MappingEvoked Potentials, MotorEvoked Potentials, SomatosensoryFemaleMotor CortexMovementNerve NetRatsRats, Sprague-DawleySpinal Cord Stimulationmotor cortexmovement controlneuromodulationrehabilitationspinal cord

Identifiers

PMID25673738
PMCPMC4416633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.