ArticleProceedings. Biological sciences2015
Who is the puppet master? Replication of a parasitic wasp-associated virus correlates with host behaviour manipulation.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation.Scientific reports · 2020Pooled it
- Ancient and current association of theJournal of virology · 2026Article
- AnvRV virus in the parasitoid waspMicrobiology spectrum · 2026Article
- A Parasitoid of Aphids Manipulates Host Mummification Site, With Effects on Survival but Not Hyperparasitism.Ecology and evolution · 2026Article
- Unveiling the RNA virus landscape ofVirus evolution · 2026Article
- Mycoviruses in Entomopathogenic Fungi.Viruses · 2025Review
- Discovery of a novel double-stranded DNA virus associated with ant labial gland disease reveals its long-term interaction with ants.Journal of virology · 2025Article
- Review
- A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Viruses of parasites: A roadmap toward diagnostic and therapeutic development.PLoS neglected tropical diseases · 2025Review
- Does the host matter? Testing the impact of host identity on the microbiome of a trematode parasite.Parasitology research · 2025Article
- Identification and Characterization of Three Novel Iflaviruses in the Cabbage WhiteflyInsects · 2025Article
- The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.Scientific reports · 2024Article
- Entomophthovirus: an insect-derived iflavirus that infects a behavior-manipulating fungal pathogen of dipterans.G3 (Bethesda, Md.) · 2024Article
- Article
- Article
- The multispecies stinkbug iflavirus Halyomorpha halys virus detected in the multispecies stinkbug egg parasitoid microwasp, Telenomus podisi (Ashmead) (Hymenoptera: Platygastridae).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Baculovirus entry into the central nervous system ofOpen biology · 2024Article
- Host species and geography impact bee-associated RNA virus communities with evidence for isolation by distance in viral populations.ISME communications · 2024Article
- The genome sequence of a braconid wasp,Wellcome open research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many parasites modify their host behaviour to improve their own transmission and survival, but the proximate mechanisms remain poorly understood. An original model consists of the parasitoid Dinocampus coccinellae and its coccinellid host, Coleomegilla maculata; during the behaviour manipulation, the parasitoid is not in contact with its host anymore. We report herein the discovery and characterization of a new RNA virus of the parasitoid (D. coccinellae paralysis virus, DcPV). Using a combination of RT-qPCR and transmission electron microscopy, we demonstrate that DcPV is stored in the oviduct of parasitoid females, replicates in parasitoid larvae and is transmitted to the host during larval development. Next, DcPV replication in the host's nervous tissue induces a severe neuropathy and antiviral immune response that correlate with the paralytic symptoms characterizing the behaviour manipulation. Remarkably, virus clearance correlates with recovery of normal coccinellid behaviour. These results provide evidence that changes in ladybeetle behaviour most likely result from DcPV replication in the cerebral ganglia rather than by manipulation by the parasitoid. This offers stimulating prospects for research on parasitic manipulation by suggesting for the first time that behaviour manipulation could be symbiont-mediated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.