ArticleFEMS microbiology letters2015
Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance.
Article in FEMS microbiology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Acetic acid induces strain-specific metabolic adaptation ofBiotechnology reports (Amsterdam, Netherlands) · 2026Article
- ExploringApplied and environmental microbiology · 2026Article
- Synthetic Biology Approaches to Enzymology in Food and Agriculture Systems.Journal of agricultural and food chemistry · 2026Review
- Bioprocess optimization and purification of DLA produced using food and fishery waste.RSC advances · 2026Article
- Impaired Acetyl-CoA Compartmentalization Drives a Futile Lipogenic-Oxidative Cycle in N88S Seipinopathy.Cells · 2026Article
- TuningJournal of fungi (Basel, Switzerland) · 2026Article
- Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids.Biomolecules · 2024Review
- Soybean Oil Regulates the Fatty Acid Synthesis II System ofMicroorganisms · 2023Article
- How adaptive laboratory evolution can boost yeast tolerance to lignocellulosic hydrolyses.Current genetics · 2022Review
- Effects of Inhibitors Generated by Dilute Phosphoric Acid Plus Steam-Exploded Poplar onMicroorganisms · 2022Article
- Whole-Genome Transformation of Yeast Promotes Rare Host Mutations with a Single Causative SNP Enhancing Acetic Acid Tolerance.Molecular and cellular biology · 2022Article
- Formate Dehydrogenase Improves the Resistance to Formic Acid and Acetic Acid Simultaneously inInternational journal of molecular sciences · 2022Article
- Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains.Biotechnology for biofuels and bioproducts · 2022Review
- Acetic acid stress in budding yeast: From molecular mechanisms to applications.Yeast (Chichester, England) · 2021Review
- Screening lager yeast with higher ethyl-acetate production by adaptive laboratory evolution in high concentration of acetic acid.World journal of microbiology & biotechnology · 2021Article
- The Role of Yeasts and Lactic Acid Bacteria on the Metabolism of Organic Acids during Winemaking.Foods (Basel, Switzerland) · 2020Review
- Failure to Maintain Acetate Homeostasis by Acetate-Activating Enzymes Impacts Plant Development.Plant physiology · 2020Article
- Polygenic analysis of very high acetic acid tolerance in the yeastBiotechnology for biofuels · 2020Article
- Microbial response to acid stress: mechanisms and applications.Applied microbiology and biotechnology · 2020Review
- Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity.Redox biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Acetic acid-mediated inhibition of the fermentation of lignocellulose-derived sugars impedes development of plant biomass as a source of renewable ethanol. In order to overcome this inhibition, the capacity of Saccharomyces cerevisiae to synthesize acetyl-CoA from acetic acid was increased by overexpressing ACS2 encoding acetyl-coenzyme A synthetase. Overexpression of ACS2 resulted in higher resistance to acetic acid as measured by an increased growth rate and shorter lag phase relative to a wild-type control strain, suggesting that Acs2-mediated consumption of acetic acid during fermentation contributes to acetic acid detoxification.
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