ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Prevalence and Incidence of Respiratory Syncytial Virus and Other Respiratory Viral Infections in Children Aged 6 Months to 10 Years With Influenza-like Illness Enrolled in a Randomized Trial.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01051661 (A Study to Evaluate the Safety and Efficacy of A/California/7/2009), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Evaluate the Safety and Efficacy of A/California/7/2009 (H1N1)V-like Vaccines GSK2340274A and GSK2340273A in Children Aged 6 Months to Less Than 10 Years of Age
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Respiratory syncytial virus in the Western Pacific Region: a systematic review and meta-analysis.Journal of global health · 2019Pooled it
- Community-based pathogen-specific incidence of influenza-like illness due to respiratory viruses in South-central Vietnam in 2009-2012: after a pandemic of influenza A viruses.Tropical medicine and health · 2025Article
- Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010-2018.BMC medicine · 2023Article
- A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019.Virologica Sinica · 2021Article
- Epidemiology of respiratory syncytial virus in a community birth cohort of infants in the first 2 years of life.European journal of pediatrics · 2021Article
- Epidemiology of viral respiratory infections in a pediatric reference hospital in Central Panama.BMC infectious diseases · 2021Article
- Characterisation of respiratory syncytial virus activity in children and adults presenting with acute respiratory illness at primary care clinics in Singapore, 2014-2018.Influenza and other respiratory viruses · 2020Article
- Cytokines in the Respiratory Airway as Biomarkers of Severity and Prognosis for Respiratory Syncytial Virus Infection: An Update.Frontiers in immunology · 2019Review
- Evolution of Human Respiratory Syncytial Virus (RSV) over Multiple Seasons in New South Wales, Australia.Viruses · 2018Article
- Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study.The Journal of infectious diseases · 2018Article
- Reduced activation and proliferation of human lymphocytes exposed to respiratory syncytial virus compared to cells exposed to influenza virus.Journal of medical virology · 2018Article
- Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- A Virological and Phylogenetic Analysis of the Emergence of New Clades of Respiratory Syncytial Virus.Scientific reports · 2017Article
- Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012-2014.Influenza and other respiratory viruses · 2017Article
- Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample.The Journal of infection · 2017Article
- Observational
- Respiratory syncytial virus infection in infants in rural Nepal.The Journal of infection · 2016Article
- Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2016Article
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Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe high burden of respiratory syncytial virus (RSV)-associated morbidity and mortality makes vaccine development a priority.
methodsAs part of an efficacy trial of pandemic influenza vaccines (NCT01051661), RSV epidemiology in healthy children aged 6 months to <10 years at first vaccination with influenza-like illness (ILI) was evaluated in Australia, Brazil, Colombia, Costa Rica, Mexico, the Philippines, Singapore, and Thailand between February 2010 and August 2011. Active surveillance for ILI was conducted for approximately 1 year, with nasal and throat swabs analyzed by polymerase chain reaction. The prevalence and incidence of RSV among ILI episodes were calculated.
resultsA total of 6266 children were included, of whom 2421 experienced 3717 ILI episodes with a respiratory sample available. RSV was detected for 359 ILI episodes, a prevalence of 9.7% (95% confidence interval: 8.7-10.7). The highest prevalence was in children aged 12-23 or 24-35 months in all countries except the Philippines, where it was in children aged 6-11 months. The incidence of RSV-associated ILI was 7.0 (6.3-7.7) per 100 person-years (PY). Eighty-eight ILI episodes resulted in hospitalization, of which 8 were associated with RSV (prevalence 9.1% [4.0-17.1]; incidence 0.2 [0.1-0.3] per 100 PY). The incidence of RSV-associated ILI resulting in medical attendance was 6.0 (5.4-6.7) per 100 PY. RSV B subtypes were observed more frequently than A subtypes.
conclusionsActive surveillance demonstrated the considerable burden of RSV-associated illness that would not be identified through hospital-based surveillance, with a substantial part of the burden occurring in older infants and children.
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