ArticleSchizophrenia research2015
Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia.
Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oxytocin levels in individuals with schizophrenia are high in cerebrospinal fluid but low in serum: A systematic review and meta-analysis : Oxytocin and Schizophrenia.Metabolic brain disease · 2021Pooled it
- Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis.Translational psychiatry · 2020Trial
- Relationship of plasma oxytocin levels to baseline symptoms and symptom changes during three weeks of daily oxytocin administration in people with schizophrenia.Schizophrenia research · 2016Trial
- The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention.BMC psychiatry · 2026Article
- The neurobiological impact of oxytocin in mental health disorders: a comprehensive review.Annals of medicine and surgery (2012) · 2025Review
- Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.Schizophrenia (Heidelberg, Germany) · 2024Article
- Alterations of serum neuropeptide levels and their relationship to cognitive impairment and psychopathology in male patients with chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review.Brain sciences · 2023Review
- Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders.Medicina (Kaunas, Lithuania) · 2022Review
- Endogenous oxytocin levels are associated with facial emotion recognition accuracy but not gaze behavior in individuals with schizophrenia.Acta psychiatrica Scandinavica · 2022Article
- Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.International journal of molecular sciences · 2021Review
- Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia.PloS one · 2020Article
- Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis.Schizophrenia bulletin · 2019Article
- Endogenous oxytocin response to film scenes of attachment and loss is pronounced in schizophrenia.Social cognitive and affective neuroscience · 2019Article
- The association between hormones and antipsychotic use: a focus on postpartum and menopausal women.Therapeutic advances in psychopharmacology · 2019Review
- The Effect of Intranasal Oxytocin on Measures of Social Cognition in Schizophrenia: A Negative Report.Journal of psychiatry and brain science · 2019Article
- The morphometric co-atrophy networking of schizophrenia, autistic and obsessive spectrum disorders.Human brain mapping · 2018Article
- Is the serum oxytocin level altered by treatment in rheumatoid arthritis patients complicated with depression?European journal of rheumatology · 2018Article
- Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems.Genes, brain, and behavior · 2018Article
- The Relationship between the Serum Oxytocin Levels, Disease Activity, the ADLs and the QOL in Patients with Rheumatoid Arthritis.Internal medicine (Tokyo, Japan) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Lower endogenous levels of the neuropeptide oxytocin may be an important biological predictor of social cognition impairments in schizophrenia (SZ). Prior studies have demonstrated that lower-level social cognitive processes (e.g., facial affect perception) are significantly associated with reduced plasma oxytocin levels in SZ; however, it is unclear whether higher-level social cognition, which requires inferential processes and knowledge not directly presented in the stimulus, is associated with endogenous oxytocin. The current study explored the association between endogenous oxytocin levels and lower- and higher-level social cognition in 40 individuals diagnosed with SZ and 22 demographically matched healthy controls (CN). All participants received the Social Cue Recognition Test (SCRT), which presents participants with videotaped interpersonal vignettes and subsequent true/false questions related to concrete or abstract aspects of social interactions in the vignettes. Results indicated that SZ had significantly higher plasma oxytocin concentrations than CN. SZ and CN did not differ on SCRT hits, but SZ had more false positives and lower sensitivity scores than CN. Higher plasma oxytocin levels were associated with better sensitivity scores for abstract items in CN and fewer false positives for concrete items in individuals with SZ. Findings indicate that endogenous oxytocin levels predict accurate encoding of lower-level socially relevant information in SZ.
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