Evidence map›Paper›PMID 25673412›Full record

SynthesisNature2015

New genetic loci link adipose and insulin biology to body fat distribution.

Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, Reedik Mägi, Rona J Strawbridge, Tune H Pers, Krista Fischer, Anne E Justice and 409 more

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04699448 (Genetic Predisposition and Body Weight Regulation. Evaluation of Target-genes in Overweight and Obese Adults, Under Different Dietary Interventions.), which is not on this map. Cited by 985 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
985citing papers in PubMed, 14 pooled it
134.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04699448 nacompletednot on this mapstarted 2020, after this paper: background citation

Genetic Predisposition and Body Weight Regulation. Evaluation of Target-genes in Overweight and Obese Adults, Under Different Dietary Interventions.

TypeinterventionalSponsorHarokopio UniversityRan2020 to 2021Enrolled202ConditionsGene-diet Interactions, Overweight and Obesity, Body Weight Changes, Health StatusArmsNutritional intervention.
3 · Its place in the literature

Who cites it

985 citing papers in PubMed, 14 syntheses or guidelines pooled it, 1,702 citations in OpenAlex.

  1. Pooled it
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  5. Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  15. Trial
  16. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  17. Article
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  19. The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026
    Review
  20. Article

925 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

419 authors at 20 institutions in 34 countries.

Dmitry Shungin *Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.
Thomas W Winkler *Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Damien C Croteau-Chonka *Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Teresa Ferreira *Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Adam E Locke *Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Reedik Mägi *Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rona J StrawbridgeAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Tune H PersDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.
Krista FischerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tsegaselassie WorkalemahuDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Joseph M W WuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Martin L BuchkovichDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Nancy L Heard-CostaNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.
Tamara S RomanDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Alexander W DrongWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ci SongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Stefan GustafssonScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Tonu EskoEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Tove FallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Zoltán KutalikInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Joshua C RandallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
André ScheragInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
Sailaja VedantamDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Jin ChenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Rudolf FehrmannDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Bratati KahaliDepartment of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Denise AndersonTelethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia.
Marian BeekmanNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Jennifer L Bragg-GreshamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Steven BuyskeDepartment of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Toby JohnsonSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Marcus E KleberVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
Kati KristianssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Irene Mateo LeachDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Carolina Medina-GomezNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Cameron D PalmerDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Sonali PechlivanisInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
Marjolein J PetersNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Alena StančákováUniversity of Eastern Finland, FI-70210 Kuopio, Finland.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Jana V Van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Loïc YengoCNRS UMR 8199, F-59019 Lille, France.
Weihua ZhangEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Johan ÄrnlövScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Gillian M ArscottPathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Amy BarrettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Claire BellisDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Amanda J BennettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Christian BerneDepartment of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden.
Matthias BlüherIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Stefan BöhringerNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Fabrice BonnetInserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France.
Yvonne BöttcherIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Marcel BruinenbergLifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Delia B CarbaUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Ida H CaspersenDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Robert ClarkeClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
E Warwick DawDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joris DeelenNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Ewa DeelmanInformation Sciences Institute, University of Southern California, Marina del Rey, California, USA.
Graciela DelgadoVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
Alex Sf DoneyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Niina EklundNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Michael R ErdosMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Karol EstradaBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.
Elodie EuryCNRS UMR 8199, F-59019 Lille, France.
Nele FriedrichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden.
Bruna GiganteDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Alan S GoKaiser Permanente, Division of Research, Oakland, CA 94612, USA.
Alain GolayService of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland.
Harald GrallertInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Tanja B GrammerVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
Jürgen GräßlerDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Jagvir GrewalEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Toomas HallerEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Goran HallmansDepartment of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK.
Kauko HeikkiläHjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
Karl-Heinz HerzigInstitute of Biomedicine, University of Oulu, Oulu, Finland.
Quinta HelmerNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Hans L HillegeDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Oddgeir HolmenDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
Steven C HuntCardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Alan L JamesDepartment of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.
Ingegerd JohanssonDepartment of Odontology, Umeå University, Umeå 901 85, Sweden.
Thorhildur JuliusdottirWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ioanna-Panagiota KalafatiDepartment of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Leena KinnunenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Wolfgang KoenigDepartment of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany.
Ishminder K KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Wolfgang KratzerDepartment of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
Claudia LaminaDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria.
Karin LeanderDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Nanette R LeeUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Jaana LindströmNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Stéphane LobbensCNRS UMR 8199, F-59019 Lille, France.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
François MachCardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
Patrik Ke MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Sigrun MergerDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Rebecca MillsEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Alireza MoayyeriDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Keri L MondaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Simon P MooijaartNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Thomas W MühleisenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
Gabriele MüllerCenter for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Ramaiah NagarajaLaboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Nicola GloriosoHypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
Ilja M NolteDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Matthias OldenDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Nigel W RaynerWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Frida RenstromDepartment of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Neil R RobertsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Salome ScholtensLifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Bengt SennbladAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
Colleen M SitlaniDepartment of Medicine, University of Washington, Seattle, WA 98101, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur 201, Iceland.
Kathleen StirrupsWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Johan SundströmDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Morris A SwertzDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Ann-Christine SyvänenScience for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Bamidele O TayoDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA.
Barbara ThorandGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Gudmar ThorleifssondeCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
Andreas TomaschitzDepartment of Cardiology, Medical University of Graz, Graz 8036, Austria.
Chiara TroffaHypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
Floor Va van OortDepartment of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Judith M VonkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Lindsay L WaiteHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Roman WennauerDepartment of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew WongMRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Qunyuan ZhangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Eoin P BrennanDiabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland.
Murim ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Per ErikssonAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Lasse FolkersenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Anders Franco-CerecedaCardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
Ali G GharaviDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA.
Åsa K HedmanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Marie-France HivertDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA.
Jinyan HuangState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Sarah KeildsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Krzysztof KirylukDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA.
Liming LiangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Richard P LiftonDepartment of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA.
Baoshan MaDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Amy J McKnightNephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, Co. Down BT9 7AB, UK.
Ruth McPhersonUniversity of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Josine L MinSchool of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Miriam F MoffattNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Joanne M MurabitoNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.
George NicholsonDepartment of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
Dale R NyholtQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Christian OlssonCardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
John Rb PerryWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Eva ReinmaaEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Rany M SalemDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.
Niina SandholmDepartment of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland.
Eric E SchadtIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Lisette StolkNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Edgar E VallejoComputer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Krina T ZondervanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
ADIPOGen Consortium
CARDIOGRAMplusC4D Consortium
CKDGen Consortium
GEFOS Consortium
GENIE Consortium
GLGC
ICBP
International Endogene Consortium
LifeLines Cohort Study
MAGIC Investigators
MuTHER Consortium
PAGE Consortium
ReproGen Consortium
Philippe AmouyelInstitut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France.
Dominique ArveilerDepartment of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
Stephan Jl BakkerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
John BeilbyPathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.
Richard N BergmanCedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Morris J BrownClinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Michel BurnierService of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Simone Claudi-BoehmDivision of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Dana C CrawfordCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Eco Jc de GeusBiological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.
Raimund ErbelClinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany.
Johan G ErikssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ele FerranniniDepartment of Internal Medicine, University of Pisa, Pisa, Italy.
Jean FerrièresDepartment of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Terrence ForresterUWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Oscar H FrancoNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Ron T GansevoortDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
Andrew T HattersleyInstitute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
Markku HeliövaaraNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Andrew A HicksCenter for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany.
Aroon D HingoraniInstitute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Wolfgang HoffmannInstitute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Albert HofmanNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK.
Elina HyppönenSansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Berit JohansenDepartment of Biology, Norwegian University of Science and Technology, Trondheim, Norway.
Pekka JousilahtiNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Antti M JulaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jaakko KaprioNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Frank KeeUK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland.
Sirkka M Keinanen-KiukaanniemiInstitute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
Jaspal S KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Peter KovacsIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Aldi T KrajaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Kari KuulasmaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Johanna KuusistoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland.
Valeriya LyssenkoSteno Diabetes Center A/S, Gentofte DK-2820, Denmark.
Satu MännistöNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André MaretteInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.
Tara C MatiseDepartment of Genetics, Rutgers University, Piscataway, NJ USA.
Colin A McKenzieUWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
Stefan MöhlenkampClinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany.
Andrew D MorrisMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Mari NelisEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Lyle J PalmerEpidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada.
Brenda W PenninxInstitute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands.
Annette PetersResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
D C RaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Marylyn D RitchieCenter for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA.
Igor RudanCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.
Veikko SalomaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Jouko SaramiesSouth Carelia Central Hospital, 53130 Lappeenranta, Finland.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Peter Eh SchwarzDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Alan R ShuldinerDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jan A StaessenDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands.
Valgerdur SteinthorsdottirdeCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
Ronald P StolkDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Anke TönjesIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Angelo TremblayDepartment of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada.
Elena TremoliDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland.
James F WilsonCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK.
Jacqueline C WittemanDepartment of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
Murielle BochudInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Bernhard O BoehmLee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.
Stefan R BornsteinDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Stéphane CauchiCNRS UMR 8199, F-59019 Lille, France.
Mark J CaulfieldClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
John C ChambersEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Richard S CooperDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA.
George DedoussisDepartment of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA.
Philippe FroguelDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Hans-Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.
Anders HamstenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Jennie HuiPathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.
Kristian HveemDepartment of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Diana KuhMRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Markku LaaksoDepartment of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Winfried MärzVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.
Patricia B MunroeClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Inger NjølstadDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Colin Na PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Markus PerolaEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Louis PérusseInstitute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Chris PowerPopulation, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Fernando RivadeneiraNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Timo E SaaristoFinnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.
Danish SaleheenBiological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
Juha SinisaloHelsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.
P Eline SlagboomNetherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Harold SniederDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Kari StefanssondeCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
Michael StumvollIntegrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Jaakko TuomilehtoNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André G UitterlindenNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Pim van der HarstDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Giovanni VeronesiEPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
H-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.
Goncalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Panos DeloukasWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Leif C GroopInstitute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
David J HunterChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Robert C KaplanAlbert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Lu QiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
David SchlessingerLaboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
David P StrachanDivision of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK.
Unnur ThorsteinsdottirdeCODE Genetics, Amgen inc., Reykjavik 101, Iceland.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
Peter M VisscherQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Jian YangQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Joel N HirschhornDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.
M Carola ZillikensNetherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Elizabeth K SpeliotesDepartment of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Caroline S FoxNational Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Paul W FranksDepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.
Erik IngelssonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Ruth Jf LoosMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
University Medical Center Groningen · NLCentre for Human Genetics · GBUppsala University · SEUniversity of North Carolina at Chapel Hill · USUniversität Ulm · DEBroad Institute · USUniversity of Eastern Finland · FIErasmus MC · NLHarvard University · USUniversity of Cambridge · GBBrigham and Women's Hospital · USLeiden University Medical Center · NLUniversity of Michigan · USWashington University in St. Louis · USCentre National de la Recherche Scientifique · FRKing's College London · GBdeCODE Genetics (Iceland) · ISKarolinska Institutet · SEQueen Mary University of London · GBUniversity of Helsinki · FI

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
British Heart Foundation BHF_FS/14/55/30806British Heart Foundation BHF_RG/08/008/25291British Heart Foundation BHF_RG/08/014/24067British Heart Foundation BHF_RG/10/12/28456British Heart Foundation BHF_RG/13/2/30098British Heart Foundation FS/14/55/30806British Heart Foundation RG/07/008/23674British Heart Foundation RG/08/008/25291British Heart Foundation RG/08/014/24067British Heart Foundation RG/10/12/28456British Heart Foundation RG/13/2/30098Cancer Research UK 14136Cancer Research UK CRUK_14136Chief Scientist Office CSO_CZB/4/710Chief Scientist Office CZB/4/710Diabetes UK 12/0004470Diabetes UK DUK_12/0004470Intramural NIH HHS Z01 HG000024Medical Research Council G0100222Medical Research Council G0400491Medical Research Council G0401527Medical Research Council G0600717Medical Research Council G0601261Medical Research Council G0601463Medical Research Council G0902037Medical Research Council G1000143Medical Research Council G1000616Medical Research Council G1001799Medical Research Council G19/35Medical Research Council G8802774Medical Research Council G9521010Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A100_1003Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5Medical Research Council MC_UU_12019/1Medical Research Council MRC_G0401527Medical Research Council MRC_G0601261Medical Research Council MRC_G0601463Medical Research Council MRC_G1000143Medical Research Council MRC_G1001799Medical Research Council MRC_G9521010Medical Research Council MRC_MC_PC_U127561128Medical Research Council MRC_MC_U106179471Medical Research Council MRC_MC_U106179472Medical Research Council MRC_MC_UP_A100_1003Medical Research Council MRC_MC_UP_A620_1014Medical Research Council MRC_MC_UU_12011/1Medical Research Council MRC_MC_UU_12012/1Medical Research Council MRC_MC_UU_12013/1Medical Research Council MRC_MC_UU_12015/1Medical Research Council MRC_MC_UU_12015/2Medical Research Council MRC_MC_UU_12015/5Medical Research Council MRC_MC_UU_12019/1Medical Research Council MRC_MR/K006584/1Medical Research Council MRC_MR/K011480/1Medical Research Council MRC_MR/K013351/1Medical Research Council MRC_MR/L003120/1Medical Research Council MRC_MR/N01104X/1Medical Research Council MR/K006584/1Medical Research Council MR/K011480/1Medical Research Council MR/K013351/1Medical Research Council MR/L003120/1Medical Research Council MR/N01104X/1NCI NIH HHS P30 CA071789NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA182913NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHLBI NIH HHS K01 HL116770NHLBI NIH HHS R00 HL094535NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL069768NIA NIH HHS R01 AG025941NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG041517NIA NIH HHS U01 AG049505NICHD NIH HHS U54 HD083211NIDA NIH HHS R21 DA027040NIDDK NIH HHS K23 DK080145NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30 DK079637NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK107437NIDDK NIH HHS U01 DK062370NIGMS NIH HHS P30 GM103341NIGMS NIH HHS T32 GM007092NIGMS NIH HHS T32 GM067553NIMHD NIH HHS P20 MD006899Wellcome Trust 084766Wellcome Trust 085235Wellcome Trust 097117Wellcome Trust 098017Wellcome Trust 098381Wellcome Trust 098498Wellcome Trust 100574Wellcome Trust WT084766Wellcome Trust WT085235Wellcome Trust WT097117Wellcome Trust WT098017Wellcome Trust WT098381Wellcome Trust WT098498Wellcome Trust WT100574
6 · The paper itself

Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Indexed as

Body Fat DistributionGenome-Wide Association StudyAdipocytesAdipogenesisAdipose TissueAge FactorsBody Mass IndexEpigenesis, GeneticEuropeFemaleGenome, HumanHumansInsulinInsulin ResistanceMaleModels, BiologicalInsulin

Identifiers

PMID25673412
PMCPMC4338562
OpenAlexW2047783882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.