ArticleOccupational and environmental medicine2015
Occupational exposure to diesel engine exhaust and alterations in lymphocyte subsets.
Article in Occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of inhaled tier-2 diesel engine exhaust on immunotoxicity in a rat model: A hazard identification study. Part II. Immunotoxicology.Toxicology reports · 2024Article
- Urinary Amino-PAHs in relation to diesel engine emissions and urinary mutagenicity.International journal of hygiene and environmental health · 2023Article
- Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA.Occupational and environmental medicine · 2023Article
- Occupational exposure to diesel engine exhaust and serum levels of microRNAs in a cross-sectional molecular epidemiology study in China.Environmental and molecular mutagenesis · 2023Article
- Association between diesel exhaust exposure and mitochondrial DNA methylation.Carcinogenesis · 2022Article
- Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin.Environmental toxicology and pharmacology · 2022Article
- Proteomic analysis of serum in workers exposed to diesel engine exhaust.Environmental and molecular mutagenesis · 2022Article
- Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust.Occupational and environmental medicine · 2021Article
- Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust.Environmental and molecular mutagenesis · 2021Article
- Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure.Environment international · 2020Article
- Diesel Exhaust and Lung Cancer-Aftermath of Becoming an IARC Group 1 Carcinogen.American journal of epidemiology · 2018Article
- Occupational exposure to diesel engine exhaust and serum cytokine levels.Environmental and molecular mutagenesis · 2018Article
- Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China.Carcinogenesis · 2017Article
- Spectrum of T-lymphocyte activities regulating allergic lung inflammation.Immunological reviews · 2017Review
- Long-term exposure to diesel engine exhaust affects cytokine expression among occupational population.Toxicology research · 2016Article
- Regression Discontinuity for Causal Effect Estimation in Epidemiology.Current epidemiology reportsReview
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 10 institutions in 5 countries.
Funding
Abstract
backgroundThe International Agency for Research on Cancer recently classified diesel engine exhaust (DEE) as a Group I carcinogen based largely on its association with lung cancer. However, the exposure-response relationship is still a subject of debate and the underlying mechanism by which DEE causes lung cancer in humans is not well understood.
methodsWe conducted a cross-sectional molecular epidemiology study in a diesel engine truck testing facility of 54 workers exposed to a wide range of DEE (ie, elemental carbon air levels, median range: 49.7, 6.1-107.7 µg/m(3)) and 55 unexposed comparable controls.
resultsThe total lymphocyte count (p=0.00044) and three of the four major lymphocyte subsets (ie, CD4+ T cells (p=0.00019), CD8+ T cells (p=0.0058) and B cells (p=0.017)) were higher in exposed versus control workers and findings were highly consistent when stratified by smoking status. In addition, there was evidence of an exposure-response relationship between elemental carbon and these end points (ptrends<0.05), and CD4+ T cell levels were significantly higher in the lowest tertile of DEE exposed workers compared to controls (p=0.012).
conclusionsOur results suggest that DEE exposure is associated with higher levels of cells that play a key role in the inflammatory process, which is increasingly being recognised as contributing to the aetiology of lung cancer. IMPACT: This study provides new insights into the underlying mechanism of DEE carcinogenicity.
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