ArticleMolecular medicine reports2015
Zinc ion implantation‑deposition technique improves the osteoblast biocompatibility of titanium surfaces.
Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Incorporating zinc ion into titanium surface promotes osteogenesis and osteointegration in implantation early phase.Journal of materials science. Materials in medicine · 2023Article
- Impact of exogenous metal ions on peri-implant bone metabolism: a review.RSC advances · 2021Review
- Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration.RSC advances · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma immersion ion implantation and deposition (PIIID) technique was used to implant zinc (Zn) ions into smooth surfaces of pure titanium (Ti) disks for investigation of tooth implant surface modification. The aim of the present study was to evaluate the surface structure and chemical composition of a modified Ti surface following Zn ion implantation and deposition and to examine the effect of such modification on osteoblast biocompatibility. Using the PIIID technique, Zn ions were deposited onto the smooth surface of pure Ti disks. The physical structure and chemical composition of the modified surface layers were characterized by scanning electron microscopy (SEM) and X‑ray photoelectron spectroscopy (XPS), respectively. In vitro culture assays using the MG‑63 bone cell line were performed to determine the effects of Zn‑modified Ti surfaces following PIIID on cellular function. Acridine orange staining was used to detect cell attachment to the surfaces and cell cycle analysis was performed using flow cytometry. SEM revealed a rough 'honeycomb' structure on the Zn‑modified Ti surfaces following PIIID processing and XPS data indicated that Zn and oxygen concentrations in the modified Ti surfaces increased with PIIID processing time. SEM also revealed significantly greater MG‑63 cell growth on Zn‑modified Ti surfaces than on pure Ti surfaces (P<0.05). Flow cytometric analysis revealed increasing percentages of MG‑63 cells in S phase with increasing Zn implantation and deposition, suggesting that MG‑63 apoptosis was inhibited and MG‑63 proliferation was promoted on Zn‑PIIID‑Ti surfaces. The present results suggest that modification with Zn‑PIIID may be used to improve the osteoblast biocompatibility of Ti implant surfaces.
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