ArticleEuropean journal of nuclear medicine and molecular imaging2015
Relationships between myocardial perfusion abnormalities and poststress left ventricular functional impairment on cadmium-zinc-telluride imaging.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Prognostic impact of cardiac resynchronization therapy guided by phase analysis: a CZT study.European heart journal. Imaging methods and practice · 2023Article
- Prognostic impact of patients' management based on anatomic/functional phenotype: a study in patients with chronic coronary syndromes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Dynamic ultrafast CZT imaging: Time for a paradigm change in myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Left ventricular eccentricity index measured with SPECT myocardial perfusion imaging: An additional parameter of adverse cardiac remodeling.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Automatic evaluation of myocardial perfusion on SPECT: Need for "Normality".Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: A CZT analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Stress-induced alteration of left ventricular eccentricity: An additional marker of multivessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Relationships between left ventricular sympathetic innervation and diastolic dysfunction: the role of myocardial innervation/perfusion mismatch.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Myocardial ischemia in the absence of obstructive coronary lesion: The role of post-stress diastolic dysfunction in detecting early coronary atherosclerosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Detection of ischemia with early myocardial perfusion imaging: You see more if you watch before.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Accuracy of myocardial perfusion imaging in detecting multivessel coronary artery disease: A cardiac CZT study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- One year of nuclear cardiology in Europe.Annals of nuclear medicine · 2016Review
- CZT camera: moving beyond classical CAD detection?European journal of nuclear medicine and molecular imaging · 2015Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the interplay between myocardial ischaemic burden and poststress left ventricular (LV) systolic and diastolic abnormalities in patients with suspected or known coronary artery disease (CAD).
methodsA total of 471 patients underwent myocardial perfusion imaging by cadmium-zinc-telluride scintigraphy and coronary angiography. A fast imaging protocol was used with stress imaging performed 10 - 15 min after tracer injection. The summed difference score (SDS) and the percent stress-to-rest ratios for LV ejection fraction and peak filling rate (PFR), measures of stress-induced systolic and diastolic impairment, were computed from scintigraphic images. A SDS of >3 was considered abnormal and >7 a marker of moderate-to-severe ischaemia.
resultsOf the 471 patients, 321 (68%) showed significant CAD in one (27%), two (23%) or three (18%) vessels. The extent of CAD associated with gradual alterations in SDS (P < 0.001). Interestingly, while impairment in the percent stress-to-rest PFR ratio paralleled the increase in the extent of CAD (P < 0.001 for trend), the occurrence of significant stress-induced systolic dysfunction was limited to patients with multivessel disease (P < 0.001 vs. patients without CAD, and P = 0.002 vs. patients with single-vessel disease). Similarly, while a strict correlation between percent stress-to-rest PFR ratio and myocardial ischaemic burden was evident (P < 0.001), significant stress-induced LV systolic impairment was limited to patients with moderate-to-severe ischaemia (P < 0.001 vs. patients with no or mild ischaemia).
conclusionStress-induced LV diastolic impairment is associated with a less extensive ischaemic burden and CAD extent than poststress systolic dysfunction, which is limited to patients with multivessel CAD.
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