ArticleJournal of cancer research and clinical oncology2015
Zinc distribution within breast cancer tissue: A possible marker for histological grading?
Article in Journal of cancer research and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Impact of Histological Processing on Endogenous Elemental Contents and Distributions in Breast Cancer Tissue Sections.Chemical & biomedical imaging · 2026Article
- Quantitative distribution of essential elements and non-essential metals in breast cancer tissues by LA-ICP-TOF-MS.Analytical and bioanalytical chemistry · 2025Article
- The Relationship between Cancer Stage, Selected Immunological Parameters, Epstein-Barr Virus Infection, and Total Serum Content of Iron, Zinc, and Copper in Patients with Laryngeal Cancer.Journal of clinical medicine · 2024Article
- Comparison of Three Low-Molecular-Weight Fluorescent Probes for Measuring Free Zinc Levels in Cultured Mammary Cells.Nutrients · 2023Article
- A Systematic Study on Zinc-Related Metabolism in Breast Cancer.Nutrients · 2023Review
- Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer.Biological trace element research · 2022Article
- Zinc's Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis.Biomolecules · 2022Review
- Imaging zinc trafficking in vivo by positron emission tomography with zinc-62.Metallomics : integrated biometal science · 2022Article
- Facets of ICP-MS and their potential in the medical sciences-Part 1: fundamentals, stand-alone and hyphenated techniques.Analytical and bioanalytical chemistry · 2022Review
- Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA-ICP-TOFMS Imaging.Analytical chemistry · 2022Article
- Association between trace elements in cancerous and non-cancerous tissues with the risk of breast cancers in western Iran.Environmental science and pollution research international · 2022Article
- Zinc Favors Triple-Negative Breast Cancer's Microenvironment Modulation and Cell Plasticity.International journal of molecular sciences · 2021Article
- Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma.Metabolites · 2021Article
- Are trace element concentrations suitable biomarkers for the diagnosis of cancer?Redox biology · 2021Article
- The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.Cellular and molecular life sciences : CMLS · 2021Article
- Zinc distribution within breast cancer tissue of different intrinsic subtypes.Archives of gynecology and obstetrics · 2021Article
- Investigations on Zinc Isotope Fractionation in Breast Cancer Tissue UsingFrontiers in medicine · 2021Article
- Detection of lithium in breast milk and in situ elemental analysis of the mammary gland.Biomedical optics express · 2018Article
- Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration.Scientific reports · 2017Article
- Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.Biological chemistry · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFocusing on the trace metal zinc as a potential biomarker for breast cancer, the literature describes bulk zinc concentrations in breast cancer tissue to be higher than in normal tissue. From a histopathological point of view, cancer cells are intermingled with normal cells of the stroma within breast cancer tissues; therefore, bulk analysis cannot reflect this situation adequately. To address this problem, analysis of zinc distribution in histological sections is the method of choice.
methodsIn the present study, nine samples of invasive ductal and lobular breast carcinoma of histological grade 1-3 were investigated, clearly differentiating between cancer and stroma areas. Zinc concentrations were determined by laser ablation inductively coupled plasma mass spectrometry applying a calibration technique based on spiked polyacrylamide gels.
resultsDirect comparison between hematoxylin- and eosin-stained tissues and zinc contour plots revealed that zinc is enriched in cancer tissue containing tumor cells in contrast to normal stroma. Moreover, zinc concentration in carcinomatous tissues directly correlates with the histological malignancy grade.
conclusionsDifferentiation between carcinomatous tissue and stroma by determination of zinc content and the correlation of zinc concentration with the histological malignancy grade not only provides a key feature for clinical decision making for cancer therapy but also suggests the trace metal zinc as a potential biomarker for breast cancer.
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