ArticleApplied microbiology and biotechnology2015
Biosynthesis and genomic analysis of medium-chain hydrocarbon production by the endophytic fungal isolate Nigrograna mackinnonii E5202H.
Article in Applied microbiology and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
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- Endophytic bacteria isolated from Urtica dioica L.- preliminary screening for enzyme and polyphenols production.Microbial cell factories · 2023Article
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- Fungal Nomenclature: Managing Change is the Name of the Game.Open forum infectious diseases · 2023Review
- Multigene phylogeny and taxonomy of Dendryphion hydei and Torula hydei spp. nov. from herbaceous litter in northern Thailand.PloS one · 2020Article
- Overexpression of Global Regulator Talae1 Leads to the Discovery of New Antifungal Polyketides From Endophytic FungusFrontiers in microbiology · 2020Article
- A promising growth promoting Meyerozyma caribbica from Solanum xanthocarpum alleviated stress in maize plants.Bioscience reports · 2019Article
- An endophytic isolate of the fungus Yarrowia lipolytica produces metabolites that ameliorate the negative impact of salt stress on the physiology of maize.BMC microbiology · 2019Article
- Genome-scale data resolve ancestral rock-inhabiting lifestyle in Dothideomycetes (Ascomycota).IMA fungus · 2019Article
- Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America.Journal of clinical microbiology · 2018Article
- Mycofumigation through production of the volatile DNA-methylating agentThe Journal of biological chemistry · 2017Article
- Analysis of chemical constituents, antimicrobial and anticancer activities of dichloromethane extracts of Sordariomycetes sp. endophytic fungi isolated from Strobilanthes crispus.World journal of microbiology & biotechnology · 2017Article
- Fueling the future with biomass: Processes and pathways for a sustainable supply of hydrocarbon fuels and biogas.Engineering in life sciences · 2017Review
- Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway.Fungal biology · 2016Article
- Biosynthesis of hydrocarbons and volatile organic compounds by fungi: bioengineering potential.Applied microbiology and biotechnology · 2015Review
- Identification of a fungal 1,8-cineole synthase from Hypoxylon sp. with specificity determinants in common with the plant synthases.The Journal of biological chemistry · 2015Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
An endophytic fungus was isolated that produces a series of volatile natural products, including terpenes and odd chain polyenes. Phylogenetic analysis of the isolate using five loci suggests that it is closely related to Nigrograna mackinnonii CBS 674.75. The main component of the polyene series was purified and identified as (3E,5E,7E)-nona-1,3,5,7-tetraene (NTE), a novel natural product. Non-oxygenated hydrocarbons of this chain length are uncommon and desirable as gasoline-surrogate biofuels. The biosynthetic pathway for NTE production was explored using metabolic labeling and gas chromatography time of flight mass spectometer (GCMS). Two-carbon incorporation (13)C acetate suggests that it is derived from a polyketide synthase (PKS) followed by decarboxylation. There are several known mechanisms for such decarboxylation, though none have been discovered in fungi. Towards identifying the PKS responsible for the production of NTE, the genome of N. mackinnonii E5202H (ATCC SD-6839) was sequenced and assembled. Of the 32 PKSs present in the genome, 17 are predicted to contain sufficient domains for the production of NTE. These results exemplify the capacity of endophytic fungi to produce novel natural products that may have many uses, such as biologically derived fuels and commodity chemicals.
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