ArticleNanotoxicology2015
Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials.
Article in Nanotoxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
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- Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
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- In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT.Particle and fibre toxicology · 2021Article
- Understanding nano-engineered particle-cell interactions: biological insights from mathematical models.Nanoscale advances · 2021Review
- High-Throughput Screening Platform for Nanoparticle-Mediated Alterations of DNA Repair Capacity.ACS nano · 2021Article
- Predicting Cytotoxicity of Metal Oxide Nanoparticles using Isalos Analytics Platform.Nanomaterials (Basel, Switzerland) · 2020Article
- Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro.Particle and fibre toxicology · 2020Article
- Toxicity assessment of metal oxide nanomaterials usingNanoImpact · 2020Article
- Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo.Particle and fibre toxicology · 2020Article
- Is aggregated synthetic amorphous silica toxicologically relevant?Particle and fibre toxicology · 2020Article
- Impacts of Organomodified Nanoclays and Their Incinerated Byproducts on Bronchial Cell Monolayer Integrity.Chemical research in toxicology · 2019Article
- Applicability and Limitations in the Characterization of Poly-Dispersed Engineered Nanomaterials in Cell Media by Dynamic Light Scattering (DLS).Materials (Basel, Switzerland) · 2019Article
- Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity.Particle and fibre toxicology · 2019Article
- Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs.Particle and fibre toxicology · 2018Review
- The impact of nanomaterial characteristics on inhalation toxicity.Toxicology research · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In vitro high throughput screening platforms based on mechanistic injury pathways are been used for hazard assessment of engineered nanomaterials (ENM). Toxicity screening and other in vitro nanotoxicology assessment efforts in essence compare and rank nanomaterials relative to each other. We hypothesize that this ranking of ENM is susceptible to dispersion and dosimetry protocols, which continue to be poorly standardized. Our objective was to quantitate the impact of dosimetry on toxicity ranking of ENM. A set of eight well-characterized and diverse low aspect ratio ENMs, were utilized. The recently developed in vitro dosimetry platform at Harvard, which includes preparation of fairly monodispersed suspensions, measurement of the effective density of formed agglomerates in culture media and fate and transport modeling was used for calculating the effective dose delivered to cells as a function of time. Changes in the dose-response relationships between the administered and delivered dose were investigated with two representative endpoints, cell viability and IL-8 production, in the human monocytic THP-1 cells. The slopes of administered/delivered dose-response relationships changed 1:4.94 times and were ENM-dependent. The overall relative ranking of ENM intrinsic toxicity also changed considerably, matching notably better the in vivo inflammation data (R(2 )= 0.97 versus 0.64). This standardized dispersion and dosimetry methodology presented here is generalizable to low aspect ratio ENMs. Our findings further reinforce the need to reanalyze and reinterpret in vitro ENM hazard ranking data published in the nanotoxicology literature in the light of dispersion and dosimetry considerations (or lack thereof) and to adopt these protocols in future in vitro nanotoxicology testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.