Evidence map›Paper›PMID 25672807›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Risk and adverse outcomes of fractures in patients with Parkinson's disease: two nationwide studies.

Y-F Huang, Y-G Cherng, S P C Hsu, C-C Yeh, Y-C Chou, C-H Wu, T-L Chen, C-C Liao

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Trial
  3. Article
  4. Fracture incidence and osteoporosis treatment in Parkinson's disease: a population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  17. Parkinson's disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  18. Review
  19. Risk and outcomes of fracture in peripheral arterial disease patients: two nationwide cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Y-F HuangDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Y-G CherngDepartment of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
S P C HsuNeurosurgery Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
C-C YehDepartment of Surgery, China Medical University Hospital, Taichung, Taiwan.
Y-C ChouDepartment of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan.
C-H WuDepartment of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
T-L ChenSchool of Medicine, Taipei Medical University, Taipei, Taiwan.
C-C LiaoSchool of Medicine, Taipei Medical University, Taipei, Taiwan. ccliao@tmu.edu.tw.
Taipei Medical University · TWChina Medical University · TWChina Medical University Hospital · TWNational Cheng Kung University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe association between Parkinson's disease and fracture was not completely understood. This nationwide study investigated increased risk of fracture in patients with Parkinson's disease. In the nested cohort study, Parkinson's disease was associated with pneumonia, septicemia, stroke, urinary tract infection, and mortality after fracture admission.

introductionFalls are a common complication in people with Parkinson's disease (PD). This study evaluated fracture risk and post-fracture outcomes in patients with PD.

methodsWe identified 1,423 adults aged 40 years and older newly diagnosed with PD using the Taiwan National Health Insurance Research Database from 2000 to 2003. Comparison cohort consisted of 5,692 adults without PD randomly selected from the same dataset, frequency matched in age and sex. Followed-up events of fracture from January 1, 2000, until December 31, 2008, were ascertained from medical claims. Adjusted hazard ratios (HR) and 95 % confidence interval (CI) of fracture associated with PD were evaluated. Another nested cohort study of 397,766 hospitalized fracture patients analyzed for adjusted odds ratios (ORs) and 95 % CIs of adverse events after fracture among patients with and without PD between 2004 and 2010.

resultsThe incidences of fracture for people with and without PD were 39.5 and 23.9 per 1,000 person-years, respectively (p < 0.0001). Compared with control, the adjusted HR of fracture was 2.25 (95 % CI 1.97-2.58) for PD patients. Previous PD was associated with risks of pneumonia (OR 1.44, 95 % CI 1.36-1.52), septicemia (OR 1.41, 95 % CI 1.33-1.49), stroke (OR 1.40, 95 % CI 1.32-1.50), urinary tract infection (OR 1.53, 95 % CI 1.46-1.61), and mortality (OR 1.25, 95 % CI 1.15-1.35) after fracture.

conclusionsPD was associated with higher risk of fracture. Patients with PD had more complications and mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for this susceptible population.

Indexed as

Accidental FallsAdultAgedAged, 80 and overAge DistributionComorbidityFemaleFractures, BoneHospital MortalityHumansLongitudinal StudiesMaleMiddle AgedParkinson DiseasePrognosisRisk FactorsFractureMortalityParkinson’s disease

Identifiers

PMID25672807
OpenAlexW2049820000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.