Evidence map›Paper›PMID 25672543›Full record

ArticleScientific reports2015

The epileptic thalamocortical network is a macroscopic self-sustained oscillator: evidence from frequency-locking experiments in rat brains.

J L Perez Velazquez, R Guevara Erra, M Rosenblum

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Neural Synchronization from the Perspective of Non-linear Dynamics.Frontiers in computational neuroscience · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J L Perez VelazquezNeuroscience &Mental Health Programme and Division of Neurology, Hospital for Sick Children; Institute of Medical Science and Department of Paediatrics, University of Toronto, Toronto, Canada.
R Guevara ErraINSERM-CEA Cognitive Neuroimaging Unit - Point Courrier 156F-91191 Gif SUR YVETTE Cedex, France.
M RosenblumDepartment of Physics and Astronomy, University of Potsdam, Potsdam, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.

Indexed as

Biological ClocksNeural PathwaysAnimalsBrainCerebral CortexDisease Models, AnimalElectric StimulationElectroencephalographyEpilepsyEvoked PotentialsRatsThalamus

Identifiers

PMID25672543
PMCPMC4325330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.