Observational studyAnais brasileiros de dermatologia
T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states.
Observational study in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Th17 and T Regulatory Cytokines in Serum, Lesional Skin, and Stimulated Peripheral Blood Mononuclear Cell Culture Supernatants from Type 1 Leprosy Reaction Patients.The American journal of tropical medicine and hygiene · 2025Article
- Pathogenicity and virulence ofVirulence · 2022Review
- Modulation of the Response toFrontiers in microbiology · 2022Review
- Leptin Deficiency May Influence the Divergence of Cell-Mediated Immunity Between Lepromatous and Tuberculoid Leprosy Patients.Journal of inflammation research · 2022Review
- The expression of FOXP3 in lesions of several forms of leprosy in patients co-infected with HIV.PLoS neglected tropical diseases · 2021Observational
- BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation.Scientific reports · 2021Article
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- Murine experimental leprosy: Evaluation of immune response by analysis of peritoneal lavage cells and footpad histopathology.International journal of experimental pathology · 2019Article
- Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations.NPJ vaccines · 2018Article
- In situ T regulatory cells and Th17 cytokines in paired samples of leprosy type 1 and type 2 reactions.PloS one · 2018Article
- T-cell regulation in Erythema Nodosum Leprosum.PLoS neglected tropical diseases · 2017Article
- A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.Frontiers in immunology · 2017Review
- Leprosy As a Complex Infection: Breakdown of the Th1 and Th2 Immune Paradigm in the Immunopathogenesis of the Disease.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies.
objectivesThis study aimed to verify the frequency and distribution of regulatory T cells in different clinical forms and reactional states of leprosy.
methodsWe performed an immunohistochemical study on 96 leprosy cases [Indeterminate (I): 9 patients; tuberculoid tuberculoid: 13 patients; borderline tuberculoid: 26 patients; borderline borderline: 3 patients; borderline lepromatous: 8 patients; lepromatous lepromatous: 27 patients; reversal reaction: 8 patients; and erythema nodosum leprosum: 2 patients].
resultsFoxP3-positive cells were present in 100% of the cases with an average density of 2.82% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was a statistically significant increment of FoxP3 expression in patients with leprosy reversal reactions when compared with patients presenting with type I leprosy (P= 0.0228); borderline tuberculoid leprosy (P = 0.0351) and lepromatous leprosy (P = 0.0344).
conclusionsThese findings suggest that Tregs play a relevant role in the etiopathogenesis of leprosy, mainly in type I leprosy reaction.
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