Evidence map›Paper›PMID 25671690›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2015

Effects of different tidal volume ventilation on paraquat-induced acute lung injury in piglets.

Chao Lan, Jinzhu Wang, Li Li, Haina Li, Lu Li, Qianqian Su, Lu Che, Lanping Liu, Min Di

Open access · hybridAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. One-Lung Ventilation with Additional Ipsilateral Ventilation of Low Tidal Volume and High Frequency in Lung Lobectomy.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chao LanDepartment of Emergency Intensive Care Unit, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Jinzhu WangDepartment of Emergency Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Li LiDepartment of Emergency Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Haina LiDepartment of Emergency Intensive Care Unit, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Lu LiDepartment of Emergency Intensive Care Unit, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Qianqian SuDepartment of Emergency Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Lu CheDepartment of Emergency Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Lanping LiuDepartment of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
Min DiDepartment of Ultrasonography, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to explore the effects of different tidal volume (VT) ventilation on paraquat-induced acute lung injury or acute respiratory distress syndrome (ALI/ARDS) in piglets. MATERIAL AND

methodsWe developed ALI/ARDS models in piglets by intraperitoneal injection of paraquat (PQ). The piglets were randomly divided into three groups: small VT group (VT=6 ml/kg, n=6), middle VT group (VT=10 ml/kg, n=6), and large VT group (VT=15 ml/kg, n=6), with the positive end-expiratory pressure (PEEP) set as 10 cmH2O. The hemodynamics were monitored by pulse-indicated continuous cardiac output (PiCCO) and the airway pressure changes and blood gas analysis indexes were recorded at different time points. The pathological changes were observed by lung puncture.

resultsThe piglets showed ALI/ARDS in 4.5±0.8 hours after PQ intraperitoneal injection. PH, PaO2 and oxygenation indexes in the three groups all decreased after modeling success compared with baseline, and PaCO2 increased significantly. PH in the small VT group decreased most obviously after ventilation for 6 hours. PaO2 and oxygenation indexes in the small VT group showed the most obvious increase after ventilation for 2 hours and were much higher than the other two groups after ventilation for 6 hours. PaCO2 increased gradually after mechanical ventilation and the small VT group showed most obvious increase. The ELWI increased obviously after ventilation for 2 hours and then the small VT group clearly decreased. PIP and plateau pressure (Pplat) in the small VT group decreased gradually and in the middle and large VT group they increased after ventilation. The lung histopathology showed that the large VT group had the most severe damage and the small VT group had only minimal damage.

conclusionsSmall tidal volume ventilation combined with PEEP could alleviate the acute lung injury induced by paraquat and improve oxygenation.

Indexed as

Disease Models, AnimalAcute Lung InjuryAnimalsBlood Gas AnalysisCardiac OutputHemodynamicsHerbicidesInjections, IntraperitonealParaquatPositive-Pressure RespirationRespiratory Distress SyndromeSwineTidal VolumeTime FactorsHerbicidesParaquat

Identifiers

PMID25671690
PMCPMC4335577
OpenAlexW2001575068

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.