ArticlePloS one2015
Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Expression of hepatocyte nuclear factor 4 alpha, wingless-related integration site, and β-catenin in clinical gastric cancer.World journal of clinical cases · 2022Article
- Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles.Journal of diabetes research · 2021Article
- MC4R and HNF4α promoter methylation at birth contribute to triglyceride levels in childhood: A prospective cohort study.Medicine · 2019Article
- Does sex hormone-binding globulin cause insulin resistance during pubertal growth?Endocrine connections · 2019Article
- Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- The role of lineage specifiers in pancreatic ductal adenocarcinoma.Journal of gastrointestinal oncology · 2018Review
- Susceptibility background for type 2 diabetes in eleven Mexican Indigenous populations: HNF4A gene analysis.Molecular genetics and genomics : MGG · 2017Article
- Cardiometabolic risk factors and lactoferrin: polymorphisms and plasma levels in French-Canadian children.Pediatric research · 2017Article
- Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts.Scientific reports · 2017Article
- DNA methylations of MC4R and HNF4α are associated with increased triglyceride levels in cord blood of preterm infants.Medicine · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesHepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor involved in the regulation of serum glucose and lipid levels. Several HNF4A gene variants have been associated with the risk of developing type 2 diabetes mellitus. However, no study has yet explored its association with insulin resistance and the cardiometabolic risk in children. We aimed to investigate the relationship between HNF4A genetic variants and the presence of metabolic syndrome (MetS) and metabolic parameters in a pediatric population. DESIGN AND
methodsOur study included 1,749 French-Canadians aged 9, 13 and 16 years and evaluated 24 HNF4A polymorphisms that were previously identified by sequencing.
resultsAnalyses revealed that, after correction for multiple testing, one SNP (rs736824; P<0.022) and two haplotypes (P1 promoter haplotype rs6130608-rs2425637; P<0.032 and intronic haplotype rs736824-rs745975-rs3212183; P<0.025) were associated with the risk of MetS. Additionally, a significant association was found between rs3212172 and apolipoprotein B levels (coefficient: -0.14 ± 0.05; P<0.022). These polymorphisms are located in HNF4A P1 promoter or in intronic regions.
conclusionsOur study demonstrates that HNF4α genetic variants are associated with the MetS and metabolic parameters in French Canadian children and adolescents. This study, the first exploring the relation between HNF4A genetic variants and MetS and metabolic variables in a pediatric cohort, suggests that HNF4α could represent an early marker for the risk of developing type 2 diabetes mellitus.
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