ArticlePloS one2015
In vivo tactile stimulation-evoked responses in Caenorhabditis elegans amphid sheath glia.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.Nature communications · 2026Article
- Dendrite glia interactions: lessons from theFrontiers in cell and developmental biology · 2025Review
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- Shear stress sensing in C. elegans.Current biology : CB · 2024Article
- Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing.Cell reports · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- Neuron cilia constrain glial regulators to microdomains around distal neurons.bioRxiv : the preprint server for biology · 2023Article
- Protocol for glial CaSTAR protocols · 2022Article
- A glial ClC ClNeuron · 2022Article
- The Voltage-Gated Calcium Channel EGL-19 Acts on Glia to Drive Olfactory Adaptation.Frontiers in molecular neuroscience · 2022Article
- Review
- HowGenetics · 2019Review
- Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins.Nature communications · 2017Article
- [The effect of glial cells in the function and development of the nervous system in Caenorhabditis elegans].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Cell-type-specific promoters forJournal of neurogeneticsArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Glial cells are important components of the nervous system. However, how they respond to physiological stimuli in vivo remains largely unknown. In this study, we investigated the electrophysiological activities and Ca2+ responses of the C. elegans amphid sheath glia (AMsh glia) to tactile stimulation in vivo. We recorded robust inward currents and Ca2+ elevation in the AMsh cell with the delivery of tactile stimuli of varying displacements to the nose tip of the worm. Compared to the adjacent mechanoreceptor ASH neuron, the AMsh cell showed greater sensitivity to tactile stimulation. Amiloride, an epithelial Na+ channel blocker, blocked the touch-induced currents and Ca2+ signaling in the ASH neuron, but not those in the AMsh cell. Taken together, our results revealed that AMsh glial cells actively respond to in vivo tactile stimulation and likely function cell-autonomously as mechanoreceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.