Evidence map›Paper›PMID 25671612›Full record

ArticleHuman vaccines & immunotherapeutics2015

Protective capacity of proteoliposomes from Mycobacterium bovis BCG in a mouse model of tuberculosis.

Yanely Tirado, Alina Puig, Nadine Alvarez, Reinier Borrero, Alicia Aguilar, Frank Camacho, Fatima Reyes, Sonsire Fernández, José Luis Pérez, Dulce Mata Espinoza and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. BCG vaccine powder-laden and dissolvable microneedle arrays for lesion-free vaccination.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Yanely Tiradoa Institute Finlay ; La Habana , Cuba.
Alina Puig
Nadine Alvarez
Reinier Borrero
Alicia Aguilar
Frank Camacho
Fatima Reyes
Sonsire Fernández
José Luis Pérez
Dulce Mata Espinoza
Jorge Alberto Barrios Payán
María Elena Sarmiento
Mohd-Nor Norazmi
Rogelio Hernández-Pando
Armando Acosta
Finlay Institute · CUUniversity of Havana · CUMSD (Mexico) · MXUniversiti Sains Malaysia · MYHospital Universiti Sains Malaysia · MYInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is one of the most important causes of mortality and morbidity due to infectious diseases. BCG, the vaccine in use, is not fully protective against TB. In a previous study, we have shown that proteoliposomes (outer membrane extracts), obtained from BCG (PLBCG) were able to induce humoral immune responses against Mycobacterium tuberculosis (Mtb) antigens. With the objective to evaluate the protective capability of PLBCG alone or as a booster with BCG, a murine model of progressive pulmonary TB was used. Animals immunized with PLBCG adjuvanted with alum (PLBCG-Al) showed similar protection to that conferred by BCG. The group immunized with PLBCG-Al as a booster to BCG gave superior protection than BCG as evidenced by a reduction of bacterial load in lungs 2 months after infection with Mtb. Animals immunized with BCG, PLBCG-Al and this formulation as a booster of BCG, showed a significant decrease of tissue damage (percentage of pneumonic area/lung) compared with non-immunized animals. These results demonstrate that immunization with PLBCG-Al alone or as a booster to BCG induce appropriate protection against challenge with Mtb in mice and support the future evaluation of PLBCG as a promising vaccine candidate against Mtb.

Indexed as

Adjuvants, ImmunologicAlum CompoundsAnimalsBacterial LoadDisease Models, AnimalLungMaleMice, Inbred BALB CMycobacterium bovisMycobacterium tuberculosisProteolipidsTuberculosisTuberculosis VaccinesAdjuvants, ImmunologicAlum Compoundsaluminum sulfateProteolipidsproteoliposomesTuberculosis VaccinesBCGBCG, Bacillus Calmette-GuerinCFU, Colony Forming UnitMtb, Mycobacterium tuberculosisPBS, Phosphate Buffer SolutionPLBCG-Al, PLBCG adjuvanted with alumPLBCG, Proteoliposomes obtained from BCGPL Proteoliposomesprime-boostproteoliposomesSD, standard deviationTB, TuberculosisTuberculosisvaccines

Identifiers

PMID25671612
PMCPMC4517452
OpenAlexW1639367011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.